Impact of AB0-blood group incompatibility on the outcome of recipients of bone marrow transplants from unrelated donors in the Japan Marrow Donor Program

Fumihiko Kimura, Ken Sato, Shinichi Kobayashi, Takashi Ikeda, Hiroshi Sao, Shinichiro Okamoto, Koichi Miyamura, Shin Ichiro Mori, Hideki Akiyama, Makoto Hirokawa, Hitoshi Ohto, Hiroshi Ashida, Kazuo Motoyoshi

Research output: Contribution to journalArticle

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Abstract

Background: Although the AB0 blood group is one of two major antigen systems of relevance for transplantation in humans, there are still conflicting data concerning the influence of AB0 incompatibility on transplant outcome. This study investigated the effect of AB0 incompatibility in recipients of bone marrow transplants from unrelated donors. Design and Methods: We retrospectively analyzed data from 5,549 patients who underwent bone marrow transplantation from unrelated donors in the Japan Marrow Donor Program. Results: Overall survival rates in the group with major and minor mismatches were significantly lower than the rate in the AB0-identical group (AB0-identical 63.0%; major mismatch, 56.9%; minor mismatch, 57.1% at 1 year). Treatment-related mortality was higher in the major and minor mismatch groups, but there was no significant difference in the rate of relapse. Cox proportional hazards modeling showed that both major and minor AB0 incompatibility were significant risk factors for transplant-related mortality, independently of disease, patients' age, and HLA incompatibility. Delayed engraftment of neutrophils, platelets, and erythrocytes was observed in transplants with major incompatibility. There was a high incidence of grade 3 and 4 acute graft-versus-host disease in the groups with major and minor mismatches, which was caused by a high incidence of stage 2 to 4 liver graft-versus-host disease. Interestingly, the risk of grade 2 to 4 graft-versus-host disease in the major mismatch group was higher in patients with early engraftment of erythrocytes. Among the patients receiving reduced-intensity conditioning, the transplant-related mortality was also increased in AB0-incompatible transplants. Conclusions: Major and minor AB0 incompatibility have specific effects on transplant-related mortality and acute graft-versus-host disease in recipients of bone marrow transplants from unrelated donors.

Original languageEnglish
Pages (from-to)1686-1693
Number of pages8
JournalHaematologica
Volume93
Issue number11
DOIs
Publication statusPublished - 2008 Nov

Fingerprint

Blood Group Incompatibility
Unrelated Donors
Japan
Bone Marrow
Tissue Donors
Transplants
Graft vs Host Disease
Mortality
Erythrocytes
Incidence
Blood Group Antigens
Bone Marrow Transplantation
Neutrophils
Blood Platelets
Survival Rate
Transplantation
Antigens
Recurrence
Liver

Keywords

  • AB0 blood type
  • Acute graft-vs-host disease
  • Bone marrow transplantation
  • Graft failure
  • Unrelated donor

ASJC Scopus subject areas

  • Hematology

Cite this

Impact of AB0-blood group incompatibility on the outcome of recipients of bone marrow transplants from unrelated donors in the Japan Marrow Donor Program. / Kimura, Fumihiko; Sato, Ken; Kobayashi, Shinichi; Ikeda, Takashi; Sao, Hiroshi; Okamoto, Shinichiro; Miyamura, Koichi; Mori, Shin Ichiro; Akiyama, Hideki; Hirokawa, Makoto; Ohto, Hitoshi; Ashida, Hiroshi; Motoyoshi, Kazuo.

In: Haematologica, Vol. 93, No. 11, 11.2008, p. 1686-1693.

Research output: Contribution to journalArticle

Kimura, F, Sato, K, Kobayashi, S, Ikeda, T, Sao, H, Okamoto, S, Miyamura, K, Mori, SI, Akiyama, H, Hirokawa, M, Ohto, H, Ashida, H & Motoyoshi, K 2008, 'Impact of AB0-blood group incompatibility on the outcome of recipients of bone marrow transplants from unrelated donors in the Japan Marrow Donor Program', Haematologica, vol. 93, no. 11, pp. 1686-1693. https://doi.org/10.3324/haematol.12933
Kimura, Fumihiko ; Sato, Ken ; Kobayashi, Shinichi ; Ikeda, Takashi ; Sao, Hiroshi ; Okamoto, Shinichiro ; Miyamura, Koichi ; Mori, Shin Ichiro ; Akiyama, Hideki ; Hirokawa, Makoto ; Ohto, Hitoshi ; Ashida, Hiroshi ; Motoyoshi, Kazuo. / Impact of AB0-blood group incompatibility on the outcome of recipients of bone marrow transplants from unrelated donors in the Japan Marrow Donor Program. In: Haematologica. 2008 ; Vol. 93, No. 11. pp. 1686-1693.
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abstract = "Background: Although the AB0 blood group is one of two major antigen systems of relevance for transplantation in humans, there are still conflicting data concerning the influence of AB0 incompatibility on transplant outcome. This study investigated the effect of AB0 incompatibility in recipients of bone marrow transplants from unrelated donors. Design and Methods: We retrospectively analyzed data from 5,549 patients who underwent bone marrow transplantation from unrelated donors in the Japan Marrow Donor Program. Results: Overall survival rates in the group with major and minor mismatches were significantly lower than the rate in the AB0-identical group (AB0-identical 63.0{\%}; major mismatch, 56.9{\%}; minor mismatch, 57.1{\%} at 1 year). Treatment-related mortality was higher in the major and minor mismatch groups, but there was no significant difference in the rate of relapse. Cox proportional hazards modeling showed that both major and minor AB0 incompatibility were significant risk factors for transplant-related mortality, independently of disease, patients' age, and HLA incompatibility. Delayed engraftment of neutrophils, platelets, and erythrocytes was observed in transplants with major incompatibility. There was a high incidence of grade 3 and 4 acute graft-versus-host disease in the groups with major and minor mismatches, which was caused by a high incidence of stage 2 to 4 liver graft-versus-host disease. Interestingly, the risk of grade 2 to 4 graft-versus-host disease in the major mismatch group was higher in patients with early engraftment of erythrocytes. Among the patients receiving reduced-intensity conditioning, the transplant-related mortality was also increased in AB0-incompatible transplants. Conclusions: Major and minor AB0 incompatibility have specific effects on transplant-related mortality and acute graft-versus-host disease in recipients of bone marrow transplants from unrelated donors.",
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AU - Kimura, Fumihiko

AU - Sato, Ken

AU - Kobayashi, Shinichi

AU - Ikeda, Takashi

AU - Sao, Hiroshi

AU - Okamoto, Shinichiro

AU - Miyamura, Koichi

AU - Mori, Shin Ichiro

AU - Akiyama, Hideki

AU - Hirokawa, Makoto

AU - Ohto, Hitoshi

AU - Ashida, Hiroshi

AU - Motoyoshi, Kazuo

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AB - Background: Although the AB0 blood group is one of two major antigen systems of relevance for transplantation in humans, there are still conflicting data concerning the influence of AB0 incompatibility on transplant outcome. This study investigated the effect of AB0 incompatibility in recipients of bone marrow transplants from unrelated donors. Design and Methods: We retrospectively analyzed data from 5,549 patients who underwent bone marrow transplantation from unrelated donors in the Japan Marrow Donor Program. Results: Overall survival rates in the group with major and minor mismatches were significantly lower than the rate in the AB0-identical group (AB0-identical 63.0%; major mismatch, 56.9%; minor mismatch, 57.1% at 1 year). Treatment-related mortality was higher in the major and minor mismatch groups, but there was no significant difference in the rate of relapse. Cox proportional hazards modeling showed that both major and minor AB0 incompatibility were significant risk factors for transplant-related mortality, independently of disease, patients' age, and HLA incompatibility. Delayed engraftment of neutrophils, platelets, and erythrocytes was observed in transplants with major incompatibility. There was a high incidence of grade 3 and 4 acute graft-versus-host disease in the groups with major and minor mismatches, which was caused by a high incidence of stage 2 to 4 liver graft-versus-host disease. Interestingly, the risk of grade 2 to 4 graft-versus-host disease in the major mismatch group was higher in patients with early engraftment of erythrocytes. Among the patients receiving reduced-intensity conditioning, the transplant-related mortality was also increased in AB0-incompatible transplants. Conclusions: Major and minor AB0 incompatibility have specific effects on transplant-related mortality and acute graft-versus-host disease in recipients of bone marrow transplants from unrelated donors.

KW - AB0 blood type

KW - Acute graft-vs-host disease

KW - Bone marrow transplantation

KW - Graft failure

KW - Unrelated donor

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