Impact of catheter-induced iatrogenic coronary artery dissection with or without postprocedural flow impairment: A report from a Japanese multicenter percutaneous coronary intervention registry

Takahiro Hiraide, Mitsuaki Sawano, Yasuyuki Shiraishi, Ikuko Ueda, Yohei Numasawa, Shigetaka Noma, Kouji Negishi, Takahiro Ohki, Shinsuke Yuasa, Kentaro Hayashida, Hiroaki Miyata, Keiichi Fukuda, Shun Kohsaka

Research output: Contribution to journalArticle

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Abstract

Despite the ever-increasing complexity of percutaneous coronary intervention (PCI), the incidence, predictors, and in-hospital outcomes of catheter-induced coronary artery dissection (CICAD) is not well defined. In addition, there are little data on whether persistent coronary flow impairment after CICAD will affect clinical outcomes. We evaluated 17,225 patients from 15 participating hospitals within the Japanese PCI registry from January 2008 to March 2016. Associations between CICAD and in-hospital adverse cardiovascular events were evaluated using multivariate logistic regression. Outcomes of patients with CICAD with or without postprocedural flow impairment (TIMI flow 2 or 3, respectively) were analyzed. The population was predominantly male (79.4%; mean age, 68.2 ± 11.0 years); 35.6% underwent PCI for complex lesions (eg. chronic total occlusion or a bifurcation lesion.). CICAD occurred in 185 (1.1%), and its incidence gradually decreased (p < 0.001 for trend); postprocedural flow impairment was observed in 43 (23.2%). Female sex, complex PCI, and target lesion in proximal vessel were independent predictors (odds ratio [OR], 2.18; 95% confidence interval [CI], 1.53–3.10; OR, 2.19; 95% CI, 1.58–3.04; and OR, 1.55; 95% CI, 1.06–2.28, respectively). CICAD was associated with an increased risk of in-hospital adverse events (composite of new-onset cardiogenic shock and new-onset heart failure) regardless of postprocedural flow impairment (OR, 10.9; 95% CI, 5.30–22.6 and OR, 2.27; 95% CI, 1.20–4.27, respectively for flow-impaired and flow-recovered CICAD). In conclusion, CICAD occurred in roughly 1% of PCI cases; female sex, complex PCI, and proximal lesion were its independent risk factors. CICAD was associated with adverse in-hospital cardiovascular events regardless of final flow status. Our data implied that the appropriate selection of PCI was necessary for women with complex lesions.

Original languageEnglish
Article number204333
JournalPLoS One
Volume13
Issue number9
DOIs
Publication statusPublished - 2018 Sep 1

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Dissection
Catheters
coronary vessels
Percutaneous Coronary Intervention
catheters
Registries
Coronary Vessels
odds ratio
confidence interval
Odds Ratio
Confidence Intervals
incidence
Cardiogenic Shock
gender
Incidence
heart failure
Logistics
risk factors
Heart Failure
Logistic Models

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Impact of catheter-induced iatrogenic coronary artery dissection with or without postprocedural flow impairment : A report from a Japanese multicenter percutaneous coronary intervention registry. / Hiraide, Takahiro; Sawano, Mitsuaki; Shiraishi, Yasuyuki; Ueda, Ikuko; Numasawa, Yohei; Noma, Shigetaka; Negishi, Kouji; Ohki, Takahiro; Yuasa, Shinsuke; Hayashida, Kentaro; Miyata, Hiroaki; Fukuda, Keiichi; Kohsaka, Shun.

In: PLoS One, Vol. 13, No. 9, 204333, 01.09.2018.

Research output: Contribution to journalArticle

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abstract = "Despite the ever-increasing complexity of percutaneous coronary intervention (PCI), the incidence, predictors, and in-hospital outcomes of catheter-induced coronary artery dissection (CICAD) is not well defined. In addition, there are little data on whether persistent coronary flow impairment after CICAD will affect clinical outcomes. We evaluated 17,225 patients from 15 participating hospitals within the Japanese PCI registry from January 2008 to March 2016. Associations between CICAD and in-hospital adverse cardiovascular events were evaluated using multivariate logistic regression. Outcomes of patients with CICAD with or without postprocedural flow impairment (TIMI flow 2 or 3, respectively) were analyzed. The population was predominantly male (79.4{\%}; mean age, 68.2 ± 11.0 years); 35.6{\%} underwent PCI for complex lesions (eg. chronic total occlusion or a bifurcation lesion.). CICAD occurred in 185 (1.1{\%}), and its incidence gradually decreased (p < 0.001 for trend); postprocedural flow impairment was observed in 43 (23.2{\%}). Female sex, complex PCI, and target lesion in proximal vessel were independent predictors (odds ratio [OR], 2.18; 95{\%} confidence interval [CI], 1.53–3.10; OR, 2.19; 95{\%} CI, 1.58–3.04; and OR, 1.55; 95{\%} CI, 1.06–2.28, respectively). CICAD was associated with an increased risk of in-hospital adverse events (composite of new-onset cardiogenic shock and new-onset heart failure) regardless of postprocedural flow impairment (OR, 10.9; 95{\%} CI, 5.30–22.6 and OR, 2.27; 95{\%} CI, 1.20–4.27, respectively for flow-impaired and flow-recovered CICAD). In conclusion, CICAD occurred in roughly 1{\%} of PCI cases; female sex, complex PCI, and proximal lesion were its independent risk factors. CICAD was associated with adverse in-hospital cardiovascular events regardless of final flow status. Our data implied that the appropriate selection of PCI was necessary for women with complex lesions.",
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AU - Hiraide, Takahiro

AU - Sawano, Mitsuaki

AU - Shiraishi, Yasuyuki

AU - Ueda, Ikuko

AU - Numasawa, Yohei

AU - Noma, Shigetaka

AU - Negishi, Kouji

AU - Ohki, Takahiro

AU - Yuasa, Shinsuke

AU - Hayashida, Kentaro

AU - Miyata, Hiroaki

AU - Fukuda, Keiichi

AU - Kohsaka, Shun

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