Impact of Coronavirus Disease 2019 on Time Delay and Functional Outcome of Mechanical Thrombectomy in Tokyo, Japan

Masahiro Katsumata, Takahiro Ota, Junya Kaneko, Hiroyuki Jimbo, Rie Aoki, Shigeta Fujitani, Masahiko Ichijo, Masato Inoue, Keigo Shigeta, Yoshifumi Miyauchi, Yu Sakai, Hideki Arakawa, Yoshinobu Otsuka, Kenichi Ariyada, Yoshiaki Kuroshima, Takahisa Fuse, Yoshiaki Shiokawa, Teruyuki Hirano

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: An association has been reported between delays in the onset-to-door (O2D) time for mechanical thrombectomy (MT) and outbreaks of coronavirus disease 2019 (COVID-19). However, the association between other MT time courses or functional outcomes and COVID-19 outbreaks remains unclear. We compared the time courses of stroke pathways or functional outcomes in 2020 (the COVID-19 era) with those in 2019 (the pre-COVID-19 era) in Tokyo, Japan. Materials and methods: This retrospective observational study used data from the Tokyo-tama-REgistry of Acute endovascular Thrombectomy (TREAT), a multicenter registry of MT for acute large vessel occlusion in the Tokyo Metropolitan Area. Patients who had undergone acute MT from January 2019 to December 2020 were included. Patients were classified by the year they had undergone MT (2019 or 2020). Results: In total, 477 patients were analyzed. O2D time was significantly longer in 2020 (146.0 min) than in 2019 (105.0 min; p = 0.034). No significant difference in door-to-puncture time (D2P) time or modified Rankin Scale (mRS) score 0–2 at 90 days was seen between 2019 and 2020. In the subgroup analysis, O2D time was significantly longer in the first half of 2020 compared with 2019. Multivariable logistic regression analysis revealed that the year 2020 was a independent predictor of longer O2D time, but not for mRS score 0–2 at 90 days. Conclusions: Although O2D time was significantly longer in the COVID-19 compared with the pre-COVID-19 era, D2P may not be significantly delayed and functional outcomes may not be different, despite the COVID-19 pandemic.

Original languageEnglish
Article number106051
JournalJournal of Stroke and Cerebrovascular Diseases
Volume30
Issue number10
DOIs
Publication statusPublished - 2021 Oct

Keywords

  • Acute ischemic stroke
  • COVID-19
  • Epidemiology
  • Thrombectomy

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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