Impact of cytogenetics on outcome of stem cell transplantation for acute myeloid leukemia in first remission: A large-scale retrospective analysis of data from the Japan Society for Hematopoietic Cell Transplantation

Hiroyasu Ogawa, Kazuhiro Ikegame, Manabu Kawakami, Satoshi Takahashi, Hisashi Sakamaki, Takahiro Karasuno, Hiroshi Sao, Yoshihisa Kodera, Noriyuki Hirabayashi, Shinichiro Okamoto, Mine Harada, Koji Iwato, Atsuo Maruta, Mitsune Tanimoto, Keisei Kawa

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

On the basis of transplantation data from the Japan Society for Hematopoietic Cell Transplantation, we retrospectively analyzed the impact of cytogenetics at diagnosis on the outcome of transplantation in 628 patients with acute myeloid leukemia who underwent autologous (n = 200), allogeneic related (n = 363), or allogenic unrelated (n = 65) stem cell transplantation (SCY) at first complete remission. For autologous SCY, patients at good cytogenetic risk had a significantly lower relapse rate (P = .017) and a significantly higher event-free survival (EFS) (P = .013) compared with those at intermediate risk. For allogeneic SCY, patients at good cytogenetic risk had a significantly lower relapse rate (P = .019) and insignificantly higher EFS (P = .093) than those at poor risk. For unrelated SCY, there was no significant difference in relapse rate or EFS between patients at good risk and those at intermediate risk. Comparison of the 3 transplantation modalities revealed that autologous SCT patients had a significantly higher incidence of relapse compared with related or unrelated SCY patients in the intermediate-risk group but not in the good-risk group. However, there were no significant differences in EFS among the 3 transplant modalities in either of these 2 risk groups. In multivariate analysis, cytogenetics was found to be an independent predictor of relapse as well as of treatment failure.

Original languageEnglish
Pages (from-to)495-500
Number of pages6
JournalInternational Journal of Hematology
Volume79
Issue number5
DOIs
Publication statusPublished - 2004 Jun

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Cell Transplantation
Stem Cell Transplantation
Acute Myeloid Leukemia
Cytogenetics
Japan
Disease-Free Survival
Recurrence
Transplantation
Treatment Failure
Multivariate Analysis
Transplants
Incidence

Keywords

  • Acute myeloid leukemia
  • Allogeneic related stem cell transplantation
  • Allogeneic unrelated stem cell transplantation
  • Autologous stem cell transplantation
  • Cytogenetics

ASJC Scopus subject areas

  • Hematology

Cite this

Impact of cytogenetics on outcome of stem cell transplantation for acute myeloid leukemia in first remission : A large-scale retrospective analysis of data from the Japan Society for Hematopoietic Cell Transplantation. / Ogawa, Hiroyasu; Ikegame, Kazuhiro; Kawakami, Manabu; Takahashi, Satoshi; Sakamaki, Hisashi; Karasuno, Takahiro; Sao, Hiroshi; Kodera, Yoshihisa; Hirabayashi, Noriyuki; Okamoto, Shinichiro; Harada, Mine; Iwato, Koji; Maruta, Atsuo; Tanimoto, Mitsune; Kawa, Keisei.

In: International Journal of Hematology, Vol. 79, No. 5, 06.2004, p. 495-500.

Research output: Contribution to journalArticle

Ogawa, H, Ikegame, K, Kawakami, M, Takahashi, S, Sakamaki, H, Karasuno, T, Sao, H, Kodera, Y, Hirabayashi, N, Okamoto, S, Harada, M, Iwato, K, Maruta, A, Tanimoto, M & Kawa, K 2004, 'Impact of cytogenetics on outcome of stem cell transplantation for acute myeloid leukemia in first remission: A large-scale retrospective analysis of data from the Japan Society for Hematopoietic Cell Transplantation', International Journal of Hematology, vol. 79, no. 5, pp. 495-500. https://doi.org/10.1532/IJH97.03166
Ogawa, Hiroyasu ; Ikegame, Kazuhiro ; Kawakami, Manabu ; Takahashi, Satoshi ; Sakamaki, Hisashi ; Karasuno, Takahiro ; Sao, Hiroshi ; Kodera, Yoshihisa ; Hirabayashi, Noriyuki ; Okamoto, Shinichiro ; Harada, Mine ; Iwato, Koji ; Maruta, Atsuo ; Tanimoto, Mitsune ; Kawa, Keisei. / Impact of cytogenetics on outcome of stem cell transplantation for acute myeloid leukemia in first remission : A large-scale retrospective analysis of data from the Japan Society for Hematopoietic Cell Transplantation. In: International Journal of Hematology. 2004 ; Vol. 79, No. 5. pp. 495-500.
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abstract = "On the basis of transplantation data from the Japan Society for Hematopoietic Cell Transplantation, we retrospectively analyzed the impact of cytogenetics at diagnosis on the outcome of transplantation in 628 patients with acute myeloid leukemia who underwent autologous (n = 200), allogeneic related (n = 363), or allogenic unrelated (n = 65) stem cell transplantation (SCY) at first complete remission. For autologous SCY, patients at good cytogenetic risk had a significantly lower relapse rate (P = .017) and a significantly higher event-free survival (EFS) (P = .013) compared with those at intermediate risk. For allogeneic SCY, patients at good cytogenetic risk had a significantly lower relapse rate (P = .019) and insignificantly higher EFS (P = .093) than those at poor risk. For unrelated SCY, there was no significant difference in relapse rate or EFS between patients at good risk and those at intermediate risk. Comparison of the 3 transplantation modalities revealed that autologous SCT patients had a significantly higher incidence of relapse compared with related or unrelated SCY patients in the intermediate-risk group but not in the good-risk group. However, there were no significant differences in EFS among the 3 transplant modalities in either of these 2 risk groups. In multivariate analysis, cytogenetics was found to be an independent predictor of relapse as well as of treatment failure.",
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AU - Ogawa, Hiroyasu

AU - Ikegame, Kazuhiro

AU - Kawakami, Manabu

AU - Takahashi, Satoshi

AU - Sakamaki, Hisashi

AU - Karasuno, Takahiro

AU - Sao, Hiroshi

AU - Kodera, Yoshihisa

AU - Hirabayashi, Noriyuki

AU - Okamoto, Shinichiro

AU - Harada, Mine

AU - Iwato, Koji

AU - Maruta, Atsuo

AU - Tanimoto, Mitsune

AU - Kawa, Keisei

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