Impact of drusen burden on incidence of subclinical CNV with OCTA

Atsuro Uchida, Sunil K. Srivastava, Deepa Manjunath, Rishi P. Singh, Aleksandra V. Rachitskaya, Peter K. Kaiser, Jamie L. Reese, Justis P. Ehlers

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND OBJECTIVE: To evaluate the impact of drusen burden on the detection of subclinical choroidal neovascularization (CNV) on optical coherence tomography angiography (OCTA) in nonexudative age-related macular degeneration (AMD). PATIENTS AND METHODS: A subanalysis of the AVATAR study, subjects diagnosed with nonexudative AMD without subfoveal atrophy were included. Subclinical CNV was assessed using OCTA software, and drusen burden was graded utilizing the advanced retinal pigment epithelium (RPE) analysis. RESULTS: Among eligible 58 eyes, 26 eyes (45%) had high drusen burden. Of the three eyes (5%) that demonstrated subclinical CNV, only one eye had high drusen burden, and all three eyes had neovascular AMD in the fellow eye. Extrafoveal RPE atrophy (odds ratio [OR] = 20.0; 95% confidence interval [CI], 1.53-261) and older age (OR = 1.27; 95% CI, 1.01-1.59) were predictive factors for subclinical CNV. CONCLUSION: Extrafoveal RPE atrophy, older age, and fellow-eye CNV were significant risk factors for underlying subclinical CNV in nonexudative AMD.

Original languageEnglish
Pages (from-to)22-30
Number of pages9
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume51
Issue number1
DOIs
Publication statusPublished - 2020 Jan
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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    Uchida, A., Srivastava, S. K., Manjunath, D., Singh, R. P., Rachitskaya, A. V., Kaiser, P. K., Reese, J. L., & Ehlers, J. P. (2020). Impact of drusen burden on incidence of subclinical CNV with OCTA. Ophthalmic Surgery Lasers and Imaging Retina, 51(1), 22-30. https://doi.org/10.3928/23258160-20191211-03