TY - JOUR
T1 - Impact of early postoperative factors on changes in skeletal muscle mass after esophagectomy in older patients with esophageal cancer
AU - Harada, Tsuyoshi
AU - Tatematsu, Noriatsu
AU - Ueno, Junya
AU - Koishihara, Yu
AU - Konishi, Nobuko
AU - Fukushima, Takuya
AU - Fujiwara, Hisashi
AU - Fujita, Takeo
AU - Hijikata, Nanako
AU - Wada, Ayako
AU - Ishikawa, Aiko
AU - Tsuji, Tetsuya
N1 - Funding Information:
The authors thank the members of the Department of Rehabilitation medicine, Esophageal Surgery, for their support; this research would not have been possible without their cooperation. We thank Georgia Lenihan-Geels, PhD, from Edanz (https://jp.edanz.com/ac ) for editing a draft of this manuscript.
Publisher Copyright:
© 2022, The Author(s).
PY - 2023/2
Y1 - 2023/2
N2 - Background: Loss of skeletal muscle mass, measured by the skeletal muscle mass index (SMI), after esophagectomy negatively impacts prognosis. However, the information to develop novel supportive care options for preventing loss of skeletal muscle mass is limited. The purpose of this retrospective cohort study was to investigate the impact of early postoperative factors on change in SMI 4 months after curative esophagectomy in older patients with esophageal cancer. Methods: This study included 113 subjects who underwent esophagectomy between 2015 and 2020. Preoperative and postoperative SMI (cm2/m2) were calculated from computed tomography images. The percentage change in SMI 4 months after surgery (SMI%) was calculated as follows: ([postoperative SMI – preoperative SMI] ÷ preoperative SMI) × 100. Potential factors affecting percentage change of SMI after surgery were analyzed by multiple regression. Results: The mean SMI% was – 5.6%. The percentage change (per 1%) in quadriceps muscle strength in the first month after surgery (standardized β = 0.190, p = 0.048) impacted the SMI%, which was independent of age, sex, preoperative SMI, comorbidity, pathological stage, and neoadjuvant chemotherapy. Conclusion: Quadriceps muscle weakness in the first month after esophagectomy impacted the SMI% in a dose-dependent relationship.
AB - Background: Loss of skeletal muscle mass, measured by the skeletal muscle mass index (SMI), after esophagectomy negatively impacts prognosis. However, the information to develop novel supportive care options for preventing loss of skeletal muscle mass is limited. The purpose of this retrospective cohort study was to investigate the impact of early postoperative factors on change in SMI 4 months after curative esophagectomy in older patients with esophageal cancer. Methods: This study included 113 subjects who underwent esophagectomy between 2015 and 2020. Preoperative and postoperative SMI (cm2/m2) were calculated from computed tomography images. The percentage change in SMI 4 months after surgery (SMI%) was calculated as follows: ([postoperative SMI – preoperative SMI] ÷ preoperative SMI) × 100. Potential factors affecting percentage change of SMI after surgery were analyzed by multiple regression. Results: The mean SMI% was – 5.6%. The percentage change (per 1%) in quadriceps muscle strength in the first month after surgery (standardized β = 0.190, p = 0.048) impacted the SMI%, which was independent of age, sex, preoperative SMI, comorbidity, pathological stage, and neoadjuvant chemotherapy. Conclusion: Quadriceps muscle weakness in the first month after esophagectomy impacted the SMI% in a dose-dependent relationship.
KW - Esophageal cancer
KW - Esophageal surgery
KW - Geriatrics
KW - Skeletal muscle mass
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U2 - 10.1007/s41999-022-00735-0
DO - 10.1007/s41999-022-00735-0
M3 - Article
C2 - 36586085
AN - SCOPUS:85145192237
SN - 1878-7649
VL - 14
SP - 203
EP - 210
JO - European Geriatric Medicine
JF - European Geriatric Medicine
IS - 1
ER -
