Impact of geriatric factors on surgical and prognostic outcomes in elderly patients with soft-tissue sarcoma

Yusuke Tsuda, Koichi Ogura, Eisuke Kobayashi, Toru Hiruma, Shintaro Iwata, Naofumi Asano, Akira Kawai, Hirokazu Chuman, Takeshi Ishii, Hideo Morioka, Hiroshi Kobayashi, Hirotaka Kawano

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6 Citations (Scopus)

Abstract

Objective: Patients aged ≥65 years requiring surgery for soft-tissue sarcoma are a concern in an aging society. We aimed to reveal the association of clinical/geriatric factors with survival period or postoperative events in such patients who underwent surgery.Methods: We enrolled patients aged ≥65 years who underwent surgery for localized soft-tissue sarcoma at five institutions. We retrospectively collected clinical/geriatric factors and laboratory data, and analyzed their association with outcomes using univariate and multivariate analyses.Results: Among the 202 patients included, mean age at presentation was 73 years. Surgical margin was R0 in 139 patients (69%). The Eastern Cooperative Oncology Group performance status was ≥ 2 in 15 (7%). Thirty patients (15%) showed thinness (body mass index <18.49 kg/cm2). High-sensitivity-modified Glasgow prognostic score ≥1 was seen in 52 patients (26%). Multivariate analysis showed that R1 surgical margin was significantly correlated with poor sarcoma-specific survival (hazard ratio for R1 vs. R0, 3.17; P = 0.001) and event-free survival (hazard ratio for R1 vs. R0, 2.56; P < 0.001). Higher Eastern Cooperative Oncology Group performance status was significantly associated with poor sarcoma-specific survival (hazard ratio for ≥2 vs. 0 or 1, 2.15; P = 0.038), and higher sensitivity-modified Glasgow prognostic score was significantly associated with poor event-free survival (hazard ratio for ≥1 vs. 0, 1.74; P = 0.046). Severe thinness (body mass index <16.00) was a risk factor for postoperative events (odds ratio for body mass index <16.00 vs. ≥16.00, 8.15, P = 0.010).Conclusions: Negative surgical margin was associated with better survival. Coexisting conditions had an impact on outcomes in elderly soft-tissue sarcoma patients.

Original languageEnglish
Article numberhyx016
Pages (from-to)422-429
Number of pages8
JournalJapanese journal of clinical oncology
Volume47
Issue number5
DOIs
Publication statusPublished - 2017 May 1

Keywords

  • Elderly
  • Geriatric factors
  • Soft-tissue sarcoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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    Tsuda, Y., Ogura, K., Kobayashi, E., Hiruma, T., Iwata, S., Asano, N., Kawai, A., Chuman, H., Ishii, T., Morioka, H., Kobayashi, H., & Kawano, H. (2017). Impact of geriatric factors on surgical and prognostic outcomes in elderly patients with soft-tissue sarcoma. Japanese journal of clinical oncology, 47(5), 422-429. [hyx016]. https://doi.org/10.1093/jjco/hyx016