Impact of graft-versus-host disease on relapse and survival after allogeneic stem cell transplantation for pediatric leukemia

Motohiro Kato, Mio Kurata, Junya Kanda, Koji Kato, Daisuke Tomizawa, Kazuko Kudo, Nao Yoshida, Kenichiro Watanabe, Hiroyuki Shimada, Jiro Inagaki, Katsuyoshi Koh, Hiroaki Goto, Keisuke Kato, Yuko Cho, Yuki Yuza, Atsushi Ogawa, Keiko Okada, Masami Inoue, Yoshiko Hashii, Takanori Teshima & 2 others Makoto Murata, Yoshiko Atsuta

Research output: Contribution to journalArticle

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Abstract

Graft-versus-host disease (GVHD) occasionally leads to morbidity and mortality but is thought to reduce the risk of relapses in patients with a hematological malignancy. However, information on the effect of GVHD in pediatric leukemia is limited. Using a nationwide registry, we retrospectively analyzed 1526 children who underwent allogeneic stem cell transplantation for leukemia. Grades 0–I acute GVHD were associated with a higher relapse rate at three years after transplantation, at 25.4 and 24.3%, respectively, than grades II, III, or IV acute GVHD at 18.9%, 21.2%, and 2.6%, respectively. In contrast, the overall survival curve of the grades 0 and I GVHD groups (79.0% and 79.5%, respectively) approximated that of the grade II GVHD group (76.3%), and the probability of survival was worst in the severe GVHD groups (66.9% for grade III and 42.5% for grade IV). Chronic GVHD also reduced the relapse risk but conferred no survival advantage. Acute lymphoblastic leukemia was more sensitive to acute GVHD than acute myeloid leukemia (AML) while AML was more sensitive to chronic GVHD. Our study reproduced the preventive effects of GVHD against pediatric leukemia relapses but failed to demonstrate a significant survival advantage.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalBone Marrow Transplantation
DOIs
Publication statusAccepted/In press - 2018 May 24

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Stem Cell Transplantation
Graft vs Host Disease
Leukemia
Pediatrics
Recurrence
Survival
Acute Myeloid Leukemia
Hematologic Neoplasms
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Registries
Transplantation
Morbidity

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Impact of graft-versus-host disease on relapse and survival after allogeneic stem cell transplantation for pediatric leukemia. / Kato, Motohiro; Kurata, Mio; Kanda, Junya; Kato, Koji; Tomizawa, Daisuke; Kudo, Kazuko; Yoshida, Nao; Watanabe, Kenichiro; Shimada, Hiroyuki; Inagaki, Jiro; Koh, Katsuyoshi; Goto, Hiroaki; Kato, Keisuke; Cho, Yuko; Yuza, Yuki; Ogawa, Atsushi; Okada, Keiko; Inoue, Masami; Hashii, Yoshiko; Teshima, Takanori; Murata, Makoto; Atsuta, Yoshiko.

In: Bone Marrow Transplantation, 24.05.2018, p. 1-8.

Research output: Contribution to journalArticle

Kato, M, Kurata, M, Kanda, J, Kato, K, Tomizawa, D, Kudo, K, Yoshida, N, Watanabe, K, Shimada, H, Inagaki, J, Koh, K, Goto, H, Kato, K, Cho, Y, Yuza, Y, Ogawa, A, Okada, K, Inoue, M, Hashii, Y, Teshima, T, Murata, M & Atsuta, Y 2018, 'Impact of graft-versus-host disease on relapse and survival after allogeneic stem cell transplantation for pediatric leukemia', Bone Marrow Transplantation, pp. 1-8. https://doi.org/10.1038/s41409-018-0221-6
Kato, Motohiro ; Kurata, Mio ; Kanda, Junya ; Kato, Koji ; Tomizawa, Daisuke ; Kudo, Kazuko ; Yoshida, Nao ; Watanabe, Kenichiro ; Shimada, Hiroyuki ; Inagaki, Jiro ; Koh, Katsuyoshi ; Goto, Hiroaki ; Kato, Keisuke ; Cho, Yuko ; Yuza, Yuki ; Ogawa, Atsushi ; Okada, Keiko ; Inoue, Masami ; Hashii, Yoshiko ; Teshima, Takanori ; Murata, Makoto ; Atsuta, Yoshiko. / Impact of graft-versus-host disease on relapse and survival after allogeneic stem cell transplantation for pediatric leukemia. In: Bone Marrow Transplantation. 2018 ; pp. 1-8.
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AU - Tomizawa, Daisuke

AU - Kudo, Kazuko

AU - Yoshida, Nao

AU - Watanabe, Kenichiro

AU - Shimada, Hiroyuki

AU - Inagaki, Jiro

AU - Koh, Katsuyoshi

AU - Goto, Hiroaki

AU - Kato, Keisuke

AU - Cho, Yuko

AU - Yuza, Yuki

AU - Ogawa, Atsushi

AU - Okada, Keiko

AU - Inoue, Masami

AU - Hashii, Yoshiko

AU - Teshima, Takanori

AU - Murata, Makoto

AU - Atsuta, Yoshiko

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