TY - JOUR
T1 - Impact of hematological inflammatory markers on clinical outcome in patients with salivary duct carcinoma
T2 - A multiinstitutional study in Japan
AU - Kawakita, Daisuke
AU - Tada, Yuichiro
AU - Imanishi, Yorihisa
AU - Beppu, Shintaro
AU - Tsukahara, Kiyoaki
AU - Kano, Satoshi
AU - Ozawa, Hiroyuki
AU - Okami, Kenji
AU - Sato, Yuichiro
AU - Shimizu, Akira
AU - Sato, Yukiko
AU - Fushimi, Chihiro
AU - Takase, Soichiro
AU - Okada, Takuro
AU - Sato, Hiroki
AU - Otsuka, Kuninori
AU - Watanabe, Yoshihiro
AU - Sakai, Akihiro
AU - Ebisumoto, Koji
AU - Togashi, Takafumi
AU - Ueki, Yushi
AU - Ota, Hisayuki
AU - Shimura, Tomotaka
AU - Hanazawa, Toyoyuki
AU - Murakami, Shingo
AU - Nagao, Toshitaka
PY - 2017
Y1 - 2017
N2 - The prognostic role of modified Glasgow Prognostic Score (mGPS), neutrophilto- lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with salivary duct carcinoma (SDC) remains unclear. We conducted a multi-institutional retrospective cohort study of 140 SDC patients. The survival impact of these hematological markers was evaluated using multivariate proportional hazard models. High mGPS (≥1) was significantly associated with worse survival (3-year overall survival (OS): 16.7% vs 66.1%, p-value=0.003; 3-year progression-free survival (PFS): 0.0% vs 27.9%, p-value < 0.001). Additionally, high C-reactive protein (CRP) (≥0.39 mg/dl) was significantly associated with worse survival (3-year OS: 32.1% vs 68.2%, p-value=0.001; 3-year PFS: 7.1% vs 31.1%, p-value < 0.001). These associations were consistent with multivariate analysis adjusted for established prognostic factors. Although we also found significant association of high NLR (≥2.5) with OS (HR 1.80; 95% confidence interval, 1.05-3.08) in multivariate analysis, this association were inconsistent with the results of PFS. In addition, we found no significant associations of PLR with survival. In conclusion, we found that mGPS, CRP and NLR were identified as prognostic factors associated with survival in SDC patients.
AB - The prognostic role of modified Glasgow Prognostic Score (mGPS), neutrophilto- lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with salivary duct carcinoma (SDC) remains unclear. We conducted a multi-institutional retrospective cohort study of 140 SDC patients. The survival impact of these hematological markers was evaluated using multivariate proportional hazard models. High mGPS (≥1) was significantly associated with worse survival (3-year overall survival (OS): 16.7% vs 66.1%, p-value=0.003; 3-year progression-free survival (PFS): 0.0% vs 27.9%, p-value < 0.001). Additionally, high C-reactive protein (CRP) (≥0.39 mg/dl) was significantly associated with worse survival (3-year OS: 32.1% vs 68.2%, p-value=0.001; 3-year PFS: 7.1% vs 31.1%, p-value < 0.001). These associations were consistent with multivariate analysis adjusted for established prognostic factors. Although we also found significant association of high NLR (≥2.5) with OS (HR 1.80; 95% confidence interval, 1.05-3.08) in multivariate analysis, this association were inconsistent with the results of PFS. In addition, we found no significant associations of PLR with survival. In conclusion, we found that mGPS, CRP and NLR were identified as prognostic factors associated with survival in SDC patients.
KW - CRP
KW - MGPS
KW - NLR
KW - Salivary duct carcinoma
KW - Survival
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U2 - 10.18632/oncotarget.13565
DO - 10.18632/oncotarget.13565
M3 - Article
C2 - 27894101
AN - SCOPUS:85009727622
SN - 1949-2553
VL - 8
SP - 1083
EP - 1091
JO - Oncotarget
JF - Oncotarget
IS - 1
ER -