Impact of hepatitis C virus on survival in patients undergoing resection of intrahepatic cholangiocarcinoma: Report of a Japanese nationwide survey

Masaki Kaibori, Kengo Yoshii, Kosuke Kashiwabara, Takashi Kokudo, Kiyoshi Hasegawa, Namiki Izumi, Takamichi Murakami, Masatoshi Kudo, Shuichiro Shiina, Michiie Sakamoto, Osamu Nakashima, Yutaka Matsuyama, Susumu Eguchi, Tatsuya Yamashita, Tadatoshi Takayama, Norihiro Kokudo, Shoji Kubo

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: We reviewed the data of a nationwide follow-up survey to determine the impact of hepatitis C virus (HCV) infection on the outcomes of hepatectomy for mass-forming (MF) type, and combined mass-forming and periductal infiltrating (MF + PI) type intrahepatic cholangiocarcinoma (ICC). Methods: In total, 956 patients with ICC who underwent curative hepatic resection were included in this cohort study, and patients were classified according to virus status. Patients were classified according to virus status as follows: HCV-related ICC (n = 138, 14.4%), hepatitis B virus (HBV)-related ICC (n = 43, 4.5%) and non-virus-related ICC (n = 775, 81.1%). To control for variables, we used 1:1 propensity score-matching to compare outcomes after surgery between HCV-related (n = 102) and non-virus-related ICC cases (n = 102). Results: We successfully matched HCV-related and non-virus-related ICC cases with similar liver function and tumor characteristics. Patients with HCV-related ICC had significantly shorter recurrence-free survival (hazard ratio 0.62, 95% confidence interval 0.42–0.92, p = 0.016) and overall survival (hazard ratio: 0.57, 95% confidence interval: 0.37–0.88, p = 0.011) than patients with non-virus-related ICC. Cox proportional hazard analysis showed that HCV-related ICC offered a worse prognosis than non-virus-related ICC. Conclusions: HCV infection increases the risk of recurrence and worsens overall survival in patients after curative resection for MF and combined MF + PI type ICC.

Original languageEnglish
JournalHepatology Research
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • cholangiocarcinoma
  • hepatectomy
  • hepatitis viruses
  • prognosis

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Impact of hepatitis C virus on survival in patients undergoing resection of intrahepatic cholangiocarcinoma: Report of a Japanese nationwide survey'. Together they form a unique fingerprint.

Cite this