Impact of HIV Infection on Transplant Outcomes after Autologous Peripheral Blood Stem Cell Transplantation

A Retrospective Study of Japanese Registry Data

Noriyoshi Yoshinaga, Junya Kanda, Yoshinobu Aisa, Shotaro Hagiwara, Takehiko Mori, Takahiro Fukuda, Yoji Ishida, Hisako Hashimoto, Koji Iwato, Yoshinobu Kanda, Mineo Kurokawa, Hideyuki Nakazawa, Shuichi Ota, Naoyuki Uchida, Tatsuo Ichinohe, Yoshiko Atsuta, Akifumi Takaori-Kondo

Research output: Contribution to journalArticle

Abstract

Autologous stem cell transplantation (ASCT) is a treatment option for HIV-positive patients with non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). However, the prognosis after ASCT in HIV-positive Japanese patients remains unclear. The aim of this study was to evaluate the impact of HIV infection on transplant outcomes after ASCT in Japan. Using the national database of the Japan Society for Hematopoietic Cell Transplantation, we retrospectively evaluated patients with NHL (n = 3862) and MM (n = 2670) who underwent their first ASCT between 2001 and 2014. The presence of HIV antibody was used to diagnose HIV infection. Fifty-six patients with NHL (1.4%) and 23 with MM (.8%) were positive for HIV antibody. Among patients with NHL overall survival (OS) was lower in HIV-positive patients than in HIV-negative patients (5-year OS: HIV-positive patients, 44% versus HIV-negative patients, 65%; P < .001). In a multivariate analysis HIV infection was significantly associated with an increased risk of overall mortality (hazard ratio, 2.30; P < .001). The incidence of relapse was higher in HIV-positive patients (P = .036), whereas there was a similar incidence of nonrelapse mortality (P = .879). OS in patients with MM was similar between those with/without HIV infection (5-year OS: HIV-positive patients, 61% versus HIV-negative patients, 63%; P = .988). HIV infection was associated with a higher risk of overall mortality and relapse after ASCT for NHL in a Japanese population.

Original languageEnglish
JournalBiology of Blood and Marrow Transplantation
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Peripheral Blood Stem Cell Transplantation
HIV Infections
Registries
Retrospective Studies
Transplants
HIV
Stem Cell Transplantation
Non-Hodgkin's Lymphoma
Multiple Myeloma
HIV Antibodies
Survival
Mortality
Japan
Recurrence
Incidence
Cell Transplantation

Keywords

  • Autologous transplantation
  • HIV
  • Multiple myeloma
  • Non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Impact of HIV Infection on Transplant Outcomes after Autologous Peripheral Blood Stem Cell Transplantation : A Retrospective Study of Japanese Registry Data. / Yoshinaga, Noriyoshi; Kanda, Junya; Aisa, Yoshinobu; Hagiwara, Shotaro; Mori, Takehiko; Fukuda, Takahiro; Ishida, Yoji; Hashimoto, Hisako; Iwato, Koji; Kanda, Yoshinobu; Kurokawa, Mineo; Nakazawa, Hideyuki; Ota, Shuichi; Uchida, Naoyuki; Ichinohe, Tatsuo; Atsuta, Yoshiko; Takaori-Kondo, Akifumi.

In: Biology of Blood and Marrow Transplantation, 01.01.2018.

Research output: Contribution to journalArticle

Yoshinaga, N, Kanda, J, Aisa, Y, Hagiwara, S, Mori, T, Fukuda, T, Ishida, Y, Hashimoto, H, Iwato, K, Kanda, Y, Kurokawa, M, Nakazawa, H, Ota, S, Uchida, N, Ichinohe, T, Atsuta, Y & Takaori-Kondo, A 2018, 'Impact of HIV Infection on Transplant Outcomes after Autologous Peripheral Blood Stem Cell Transplantation: A Retrospective Study of Japanese Registry Data', Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2018.03.009
Yoshinaga, Noriyoshi ; Kanda, Junya ; Aisa, Yoshinobu ; Hagiwara, Shotaro ; Mori, Takehiko ; Fukuda, Takahiro ; Ishida, Yoji ; Hashimoto, Hisako ; Iwato, Koji ; Kanda, Yoshinobu ; Kurokawa, Mineo ; Nakazawa, Hideyuki ; Ota, Shuichi ; Uchida, Naoyuki ; Ichinohe, Tatsuo ; Atsuta, Yoshiko ; Takaori-Kondo, Akifumi. / Impact of HIV Infection on Transplant Outcomes after Autologous Peripheral Blood Stem Cell Transplantation : A Retrospective Study of Japanese Registry Data. In: Biology of Blood and Marrow Transplantation. 2018.
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abstract = "Autologous stem cell transplantation (ASCT) is a treatment option for HIV-positive patients with non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). However, the prognosis after ASCT in HIV-positive Japanese patients remains unclear. The aim of this study was to evaluate the impact of HIV infection on transplant outcomes after ASCT in Japan. Using the national database of the Japan Society for Hematopoietic Cell Transplantation, we retrospectively evaluated patients with NHL (n = 3862) and MM (n = 2670) who underwent their first ASCT between 2001 and 2014. The presence of HIV antibody was used to diagnose HIV infection. Fifty-six patients with NHL (1.4{\%}) and 23 with MM (.8{\%}) were positive for HIV antibody. Among patients with NHL overall survival (OS) was lower in HIV-positive patients than in HIV-negative patients (5-year OS: HIV-positive patients, 44{\%} versus HIV-negative patients, 65{\%}; P < .001). In a multivariate analysis HIV infection was significantly associated with an increased risk of overall mortality (hazard ratio, 2.30; P < .001). The incidence of relapse was higher in HIV-positive patients (P = .036), whereas there was a similar incidence of nonrelapse mortality (P = .879). OS in patients with MM was similar between those with/without HIV infection (5-year OS: HIV-positive patients, 61{\%} versus HIV-negative patients, 63{\%}; P = .988). HIV infection was associated with a higher risk of overall mortality and relapse after ASCT for NHL in a Japanese population.",
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AU - Hagiwara, Shotaro

AU - Mori, Takehiko

AU - Fukuda, Takahiro

AU - Ishida, Yoji

AU - Hashimoto, Hisako

AU - Iwato, Koji

AU - Kanda, Yoshinobu

AU - Kurokawa, Mineo

AU - Nakazawa, Hideyuki

AU - Ota, Shuichi

AU - Uchida, Naoyuki

AU - Ichinohe, Tatsuo

AU - Atsuta, Yoshiko

AU - Takaori-Kondo, Akifumi

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N2 - Autologous stem cell transplantation (ASCT) is a treatment option for HIV-positive patients with non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). However, the prognosis after ASCT in HIV-positive Japanese patients remains unclear. The aim of this study was to evaluate the impact of HIV infection on transplant outcomes after ASCT in Japan. Using the national database of the Japan Society for Hematopoietic Cell Transplantation, we retrospectively evaluated patients with NHL (n = 3862) and MM (n = 2670) who underwent their first ASCT between 2001 and 2014. The presence of HIV antibody was used to diagnose HIV infection. Fifty-six patients with NHL (1.4%) and 23 with MM (.8%) were positive for HIV antibody. Among patients with NHL overall survival (OS) was lower in HIV-positive patients than in HIV-negative patients (5-year OS: HIV-positive patients, 44% versus HIV-negative patients, 65%; P < .001). In a multivariate analysis HIV infection was significantly associated with an increased risk of overall mortality (hazard ratio, 2.30; P < .001). The incidence of relapse was higher in HIV-positive patients (P = .036), whereas there was a similar incidence of nonrelapse mortality (P = .879). OS in patients with MM was similar between those with/without HIV infection (5-year OS: HIV-positive patients, 61% versus HIV-negative patients, 63%; P = .988). HIV infection was associated with a higher risk of overall mortality and relapse after ASCT for NHL in a Japanese population.

AB - Autologous stem cell transplantation (ASCT) is a treatment option for HIV-positive patients with non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). However, the prognosis after ASCT in HIV-positive Japanese patients remains unclear. The aim of this study was to evaluate the impact of HIV infection on transplant outcomes after ASCT in Japan. Using the national database of the Japan Society for Hematopoietic Cell Transplantation, we retrospectively evaluated patients with NHL (n = 3862) and MM (n = 2670) who underwent their first ASCT between 2001 and 2014. The presence of HIV antibody was used to diagnose HIV infection. Fifty-six patients with NHL (1.4%) and 23 with MM (.8%) were positive for HIV antibody. Among patients with NHL overall survival (OS) was lower in HIV-positive patients than in HIV-negative patients (5-year OS: HIV-positive patients, 44% versus HIV-negative patients, 65%; P < .001). In a multivariate analysis HIV infection was significantly associated with an increased risk of overall mortality (hazard ratio, 2.30; P < .001). The incidence of relapse was higher in HIV-positive patients (P = .036), whereas there was a similar incidence of nonrelapse mortality (P = .879). OS in patients with MM was similar between those with/without HIV infection (5-year OS: HIV-positive patients, 61% versus HIV-negative patients, 63%; P = .988). HIV infection was associated with a higher risk of overall mortality and relapse after ASCT for NHL in a Japanese population.

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