Impact of HLA Mismatch Direction on the Outcome of Unrelated Bone Marrow Transplantation: A Retrospective Analysis from the Japan Society for Hematopoietic Cell Transplantation

HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The relative desirability of an unrelated donor with a bidirectional 1-locus mismatch (1MM-Bi), a 1-locus mismatch only in the graft-versus-host direction (1MM-GVH), or a 1-locus mismatch only in the host-versus-graft direction (1MM-HVG) is not yet clear. We analyzed adult patients with leukemia or myelodysplastic syndrome who received a first allogeneic stem cell transplant from an HLA-A, -B, -C, and -DRB1 matched or 1-allele mismatched unrelated donor in Japan. The effects of 1MM-Bi (n= 1020), 1MM-GVH (n= 83), and 1MM-HVG (n= 83) compared with a zero mismatch (0MM) (n= 2570) were analyzed after adjusting for other significant variables. The risk of grades III to IV acute graft-versus-host disease (GVHD) was higher with marginal significance in the 1MM-GVH group than in the 0MM group (hazard ratio, 1.85; P=.014). However, there was no significant difference in overall or nonrelapse mortality between the 1MM-GVH and 0MM groups. There was no significant difference in acute GVHD or overall or nonrelapse mortality between the 1MM-HVG and 0MM groups. The risks of acute GVHD and overall mortality were significantly higher in the 1MM-Bi group than in the 0MM group. These findings indicate that unrelated donors with 1MM-GVH and 1MM-HVG are both good candidates for patients without an HLA-matched unrelated donor in a Japanese cohort.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalBiology of Blood and Marrow Transplantation
Volume21
Issue number2
DOIs
Publication statusPublished - 2015 Feb 1

Fingerprint

Cell Transplantation
Bone Marrow Transplantation
Japan
Transplants
Unrelated Donors
Graft vs Host Disease
Mortality
Direction compound
HLA-A Antigens
HLA-B Antigens
Myelodysplastic Syndromes
Leukemia
Stem Cells
Alleles

Keywords

  • Donor selection
  • Graft-versus-host direction
  • GVHD
  • HLA mismatch
  • Host-versus-graft direction
  • Overall survival

ASJC Scopus subject areas

  • Transplantation
  • Hematology

Cite this

Impact of HLA Mismatch Direction on the Outcome of Unrelated Bone Marrow Transplantation : A Retrospective Analysis from the Japan Society for Hematopoietic Cell Transplantation. / HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation.

In: Biology of Blood and Marrow Transplantation, Vol. 21, No. 2, 01.02.2015, p. 305-311.

Research output: Contribution to journalArticle

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abstract = "The relative desirability of an unrelated donor with a bidirectional 1-locus mismatch (1MM-Bi), a 1-locus mismatch only in the graft-versus-host direction (1MM-GVH), or a 1-locus mismatch only in the host-versus-graft direction (1MM-HVG) is not yet clear. We analyzed adult patients with leukemia or myelodysplastic syndrome who received a first allogeneic stem cell transplant from an HLA-A, -B, -C, and -DRB1 matched or 1-allele mismatched unrelated donor in Japan. The effects of 1MM-Bi (n= 1020), 1MM-GVH (n= 83), and 1MM-HVG (n= 83) compared with a zero mismatch (0MM) (n= 2570) were analyzed after adjusting for other significant variables. The risk of grades III to IV acute graft-versus-host disease (GVHD) was higher with marginal significance in the 1MM-GVH group than in the 0MM group (hazard ratio, 1.85; P=.014). However, there was no significant difference in overall or nonrelapse mortality between the 1MM-GVH and 0MM groups. There was no significant difference in acute GVHD or overall or nonrelapse mortality between the 1MM-HVG and 0MM groups. The risks of acute GVHD and overall mortality were significantly higher in the 1MM-Bi group than in the 0MM group. These findings indicate that unrelated donors with 1MM-GVH and 1MM-HVG are both good candidates for patients without an HLA-matched unrelated donor in a Japanese cohort.",
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AU - Ichinohe, Tatsuo

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