Impact of improvement in specificity of primary screening test on total cost of prostate cancer mass screening

Takashi Kobayashi, Rei Goto, Tsuguya Fukui, Osamu Ogawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: Improvement in the specificity of primary screening tests, without significant cost elevation of the assay, provides cost savings in prostate cancer screening programs by reducing unnecessary secondary screening procedures. The purpose of this study was to evaluate the economic impact of improvement in the specificity of primary screening tests and to estimate the socially acceptable cost elevation for improved specificity. Methods: A decision-analytic model was designed to evaluate the total costs of prostate cancer mass screening according to the changes in the specificity and the cost of the primary screening test. All assumed factors were tested by three-way sensitivity analyses incorporating cost and specificity. Results: The base case analysis showed that a 1% improvement in the specificity of the primary screening test provides a $1.19 cost reduction per participant. Sensitivity analyses showed that an acceptable cost elevation for a 1% improvement in the specificity ranged from 0.68 to 2.90 $/% with respect to changes in several factors in the screening program. Conclusions: The specificity and cost of the primary screening test has a significant economical impact on prostate cancer mass screening. For each screening program, it should be taken into consideration whether the cost of the new test deserves the specificity.

Original languageEnglish
Pages (from-to)805-810
Number of pages6
JournalInternational Journal of Urology
Volume14
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1
Externally publishedYes

Keywords

  • Decision-analytic model
  • Prostate-specific antigen
  • Sensitivity analysis

ASJC Scopus subject areas

  • Urology

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