Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Stanley P.L. Leong, Markus Zuber, Robert L. Ferris, Yuko Kitagawa, Ramon Cabanas, Charles Levenback, Mark Faries, Sukamal Saha

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The validation of sentinel lymph node (SLN) concept in melanoma and breast cancer has established a new paradigm in cancer metastasis that, in general, cancer cells spread in a orderly fashion from the primary site to the SLNs in the regional nodal basin and then to the distant sites. In this review article, we examine the development of SLN concept in penile carcinoma, melanoma and breast carcinoma and its application to other solid cancers with emphasis of the relationship between micrometastasis in SLNs and clinical outcomes.

Original languageEnglish
Pages (from-to)518-530
Number of pages13
JournalJournal of Surgical Oncology
Volume103
Issue number6
DOIs
Publication statusPublished - 2011 May 1

Keywords

  • outcomes
  • sentinel lymph nodes
  • tumor burden

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Leong, S. P. L., Zuber, M., Ferris, R. L., Kitagawa, Y., Cabanas, R., Levenback, C., Faries, M., & Saha, S. (2011). Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients. Journal of Surgical Oncology, 103(6), 518-530. https://doi.org/10.1002/jso.21815