Impact of serum C-reactive protein elevation on the left ventricular spherical change and the development of mitral regurgitation after anterior acute myocardial infarction

Takashi Kohno, Toshihisa Anzai, Kotaro Naito, Yohei Ohno, Hidehiro Kaneko, Hui Chong Li, Yasuo Sugano, Yuichiro Maekawa, Shiro Iwanaga, Yasushi Asakura, Tsutomu Yoshikawa, Satoshi Ogawa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background/Aims: Mitral regurgitation (MR) is frequently observed in patients with acute myocardial infarction (AMI), and is known to convey an adverse prognosis. We sought to clarify the relationship between MR and left ventricular (LV) remodeling, in association with serum C-reactive protein (CRP) elevation. Methods/Results: A total of 181 patients with first anterior ST-elevation AMI were examined. MR was detected in 68 patients by color Doppler echocardiography 2 weeks after AMI, and the patients with MR were associated with higher incidence of readmission for heart failure. Serum CRP was serially measured, and the peak serum CRP level was markedly increased in patients with MR compared with those without MR. Multiple logistic regression analysis showed that peak CRP tertile was an independent determinant of MR after AMI (p < 0.0001). In the substudy, the increases in LV end-diastolic volume and sphericity index were higher in patients with MR than in those without MR. Conclusions: MR during the early phase of anterior AMI was associated with LV spherical change and late-phase heart failure, in association with increased serum CRP level. These findings suggest an important role of the inflammatory response in the development of ischemic MR and LV remodeling.

Original languageEnglish
Pages (from-to)386-394
Number of pages9
JournalCardiology
Volume107
Issue number4
DOIs
Publication statusPublished - 2007 May

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Mitral Valve Insufficiency
C-Reactive Protein
Blood Proteins
Myocardial Infarction
Ventricular Remodeling
Heart Failure
Doppler Color Echocardiography
Stroke Volume
Logistic Models
Regression Analysis

Keywords

  • Inflammation
  • Mitral valve
  • Remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Impact of serum C-reactive protein elevation on the left ventricular spherical change and the development of mitral regurgitation after anterior acute myocardial infarction. / Kohno, Takashi; Anzai, Toshihisa; Naito, Kotaro; Ohno, Yohei; Kaneko, Hidehiro; Li, Hui Chong; Sugano, Yasuo; Maekawa, Yuichiro; Iwanaga, Shiro; Asakura, Yasushi; Yoshikawa, Tsutomu; Ogawa, Satoshi.

In: Cardiology, Vol. 107, No. 4, 05.2007, p. 386-394.

Research output: Contribution to journalArticle

Kohno, T, Anzai, T, Naito, K, Ohno, Y, Kaneko, H, Li, HC, Sugano, Y, Maekawa, Y, Iwanaga, S, Asakura, Y, Yoshikawa, T & Ogawa, S 2007, 'Impact of serum C-reactive protein elevation on the left ventricular spherical change and the development of mitral regurgitation after anterior acute myocardial infarction', Cardiology, vol. 107, no. 4, pp. 386-394. https://doi.org/10.1159/000099057
Kohno, Takashi ; Anzai, Toshihisa ; Naito, Kotaro ; Ohno, Yohei ; Kaneko, Hidehiro ; Li, Hui Chong ; Sugano, Yasuo ; Maekawa, Yuichiro ; Iwanaga, Shiro ; Asakura, Yasushi ; Yoshikawa, Tsutomu ; Ogawa, Satoshi. / Impact of serum C-reactive protein elevation on the left ventricular spherical change and the development of mitral regurgitation after anterior acute myocardial infarction. In: Cardiology. 2007 ; Vol. 107, No. 4. pp. 386-394.
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