Impact of stem cell source and conditioning regimen on erythrocyte recovery kinetics after allogeneic haematopoietic stem cell transplantation from an ABO-incompatible donor

Yoshinobu Kanda, Ryuji Tanosaki, Kunihisa Nakai, Takeshi Saito, Mutsuko Ohnishi, Hironari Niiya, Aki Chizuka, Kimikazu Yakushijin, Norinaga Urahama, Kyoji Ueda, Kimiko Iijima, Toshihiko Ando, Hiroshi Matsubara, Masahiro Kami, Atsushi Makimoto, Yukio Kobayashi, Kensei Tobinai, Shin Mineishi, Yoichi Takaue

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16 Citations (Scopus)

Abstract

We evaluated erythrocyte recovery in 121 allogeneic haematopoietic stem cell transplantation (HSCT) recipients. There were 35 major and minor ABO-incompatible transplants, respectively, including 10 bi-directionally ABO-incompatible transplants. The use of peripheral blood stem cells facilitated erythrocyte recovery, regardless of the presence or absence of major ABO-incompatibility, and was associated with a frequent detection of anti-host isohaemagglutin early after minor ABO-incompatible transplantation, which was not associated with clinically relevant haemolysis. The use of a reduced-intensity regimen combining a purine analogue and busulphan did not delay erythrocyte recovery after major ABO-incompatible transplantation, suggesting this regimen had a strong activity against host plasma cell.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalBritish Journal of Haematology
Volume118
Issue number1
DOIs
Publication statusPublished - 2002 Jul 27
Externally publishedYes

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Keywords

  • Bone marrow transplantation
  • Erythrocyte recovery
  • Isohaemagglutin
  • Peripheral blood stem cell transplantation
  • Reduced-intensity stem cell transplantation

ASJC Scopus subject areas

  • Hematology

Cite this

Kanda, Y., Tanosaki, R., Nakai, K., Saito, T., Ohnishi, M., Niiya, H., Chizuka, A., Yakushijin, K., Urahama, N., Ueda, K., Iijima, K., Ando, T., Matsubara, H., Kami, M., Makimoto, A., Kobayashi, Y., Tobinai, K., Mineishi, S., & Takaue, Y. (2002). Impact of stem cell source and conditioning regimen on erythrocyte recovery kinetics after allogeneic haematopoietic stem cell transplantation from an ABO-incompatible donor. British Journal of Haematology, 118(1), 128-131. https://doi.org/10.1046/j.1365-2141.2002.03693.x