Impact of Stent Graft Design on External Iliac Artery Limb Occlusion Rates After Endovascular Aneurysm Repair: Post-hoc Analysis of a Japanese Multicentre Database

Tsunehiro Shintani, Hideaki Obara, Kentaro Matsubara, Keita Hayashi, Masanori Hayashi, Shigeshi Ono, Tatsuya Shimogawara, Shintaro Shibutani, Susumu Watada, Yasuhito Sekimoto, Norio Uchida, Atsunori Asami, Taku Fujii, Hirohisa Harada, Naoki Fujimura, Yasunori Sato, Yuko Kitagawa

Research output: Contribution to journalArticle

Abstract

Objective/Background: It was hypothesised that a helical stent with expanded polytetrafluoroethylene (ePTFE) grafts could provide a preventive effect for external iliac artery (EIA) limb occlusion following endovascular aortic aneurysm repair (EVAR). Therefore, a post-hoc analysis of a Japanese multicentre database was conducted to assess the impact of the stent graft design on EIA limb occlusion rates. Methods: Patients who underwent EVAR with EIA limb deployment between 2008 and 2016 were evaluated. The stent graft limbs were divided into two groups: group A comprised stent graft limbs made of a helical stent with ePTFE grafts (Excluder; n = 255), and group B comprised stent graft limbs made of a Z stent with polyester grafts (Zenith, Flex and Endurant; n = 173). The main outcome was the incidence of limb occlusion and severe limb stenosis (EIA related limb complications). The risk factors for EIA related limb complications were analysed and the midterm results between groups A and B compared. Fine–Gray generalisation of the proportional hazards model was used after propensity score matching to calculate the hazard ratio (HR). Results: One complication occurred in group A and 10 complications occurred in group B. The risk factors for EIA related limb complications for the entire group were a stent graft limb size ≤10 mm (HR 5.41; p =.01) and inclusion in group B (HR 14.9; p =.009). After propensity matching, group A (n = 159) was matched with group B (n = 159). The cumulative incidence function of EIA related limb complications at five years was 0.66% in group A and 7.8% in group B (HR 8.67; p =.039). Conclusion: Stent graft design can affect limb patency in EIA limb deployment. When EIA limb deployment is necessary for patients with a small EIA, such as Japanese patients, stent graft limbs made of a helical stent with ePTFE should be used to reduce the risk of limb occlusion.

Original languageEnglish
JournalEuropean Journal of Vascular and Endovascular Surgery
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Fingerprint

Iliac Artery
Stents
Aneurysm
Extremities
Databases
Transplants
Polytetrafluoroethylene
Aortic Aneurysm
Propensity Score
Polyesters
Incidence

Keywords

  • Abdominal aortic aneurysm
  • EIA limb occlusion
  • Endovascular aortic aneurysm repair
  • Japanese

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Impact of Stent Graft Design on External Iliac Artery Limb Occlusion Rates After Endovascular Aneurysm Repair : Post-hoc Analysis of a Japanese Multicentre Database. / Shintani, Tsunehiro; Obara, Hideaki; Matsubara, Kentaro; Hayashi, Keita; Hayashi, Masanori; Ono, Shigeshi; Shimogawara, Tatsuya; Shibutani, Shintaro; Watada, Susumu; Sekimoto, Yasuhito; Uchida, Norio; Asami, Atsunori; Fujii, Taku; Harada, Hirohisa; Fujimura, Naoki; Sato, Yasunori; Kitagawa, Yuko.

In: European Journal of Vascular and Endovascular Surgery, 01.01.2019.

Research output: Contribution to journalArticle

Shintani, Tsunehiro ; Obara, Hideaki ; Matsubara, Kentaro ; Hayashi, Keita ; Hayashi, Masanori ; Ono, Shigeshi ; Shimogawara, Tatsuya ; Shibutani, Shintaro ; Watada, Susumu ; Sekimoto, Yasuhito ; Uchida, Norio ; Asami, Atsunori ; Fujii, Taku ; Harada, Hirohisa ; Fujimura, Naoki ; Sato, Yasunori ; Kitagawa, Yuko. / Impact of Stent Graft Design on External Iliac Artery Limb Occlusion Rates After Endovascular Aneurysm Repair : Post-hoc Analysis of a Japanese Multicentre Database. In: European Journal of Vascular and Endovascular Surgery. 2019.
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abstract = "Objective/Background: It was hypothesised that a helical stent with expanded polytetrafluoroethylene (ePTFE) grafts could provide a preventive effect for external iliac artery (EIA) limb occlusion following endovascular aortic aneurysm repair (EVAR). Therefore, a post-hoc analysis of a Japanese multicentre database was conducted to assess the impact of the stent graft design on EIA limb occlusion rates. Methods: Patients who underwent EVAR with EIA limb deployment between 2008 and 2016 were evaluated. The stent graft limbs were divided into two groups: group A comprised stent graft limbs made of a helical stent with ePTFE grafts (Excluder; n = 255), and group B comprised stent graft limbs made of a Z stent with polyester grafts (Zenith, Flex and Endurant; n = 173). The main outcome was the incidence of limb occlusion and severe limb stenosis (EIA related limb complications). The risk factors for EIA related limb complications were analysed and the midterm results between groups A and B compared. Fine–Gray generalisation of the proportional hazards model was used after propensity score matching to calculate the hazard ratio (HR). Results: One complication occurred in group A and 10 complications occurred in group B. The risk factors for EIA related limb complications for the entire group were a stent graft limb size ≤10 mm (HR 5.41; p =.01) and inclusion in group B (HR 14.9; p =.009). After propensity matching, group A (n = 159) was matched with group B (n = 159). The cumulative incidence function of EIA related limb complications at five years was 0.66{\%} in group A and 7.8{\%} in group B (HR 8.67; p =.039). Conclusion: Stent graft design can affect limb patency in EIA limb deployment. When EIA limb deployment is necessary for patients with a small EIA, such as Japanese patients, stent graft limbs made of a helical stent with ePTFE should be used to reduce the risk of limb occlusion.",
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T2 - Post-hoc Analysis of a Japanese Multicentre Database

AU - Shintani, Tsunehiro

AU - Obara, Hideaki

AU - Matsubara, Kentaro

AU - Hayashi, Keita

AU - Hayashi, Masanori

AU - Ono, Shigeshi

AU - Shimogawara, Tatsuya

AU - Shibutani, Shintaro

AU - Watada, Susumu

AU - Sekimoto, Yasuhito

AU - Uchida, Norio

AU - Asami, Atsunori

AU - Fujii, Taku

AU - Harada, Hirohisa

AU - Fujimura, Naoki

AU - Sato, Yasunori

AU - Kitagawa, Yuko

PY - 2019/1/1

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N2 - Objective/Background: It was hypothesised that a helical stent with expanded polytetrafluoroethylene (ePTFE) grafts could provide a preventive effect for external iliac artery (EIA) limb occlusion following endovascular aortic aneurysm repair (EVAR). Therefore, a post-hoc analysis of a Japanese multicentre database was conducted to assess the impact of the stent graft design on EIA limb occlusion rates. Methods: Patients who underwent EVAR with EIA limb deployment between 2008 and 2016 were evaluated. The stent graft limbs were divided into two groups: group A comprised stent graft limbs made of a helical stent with ePTFE grafts (Excluder; n = 255), and group B comprised stent graft limbs made of a Z stent with polyester grafts (Zenith, Flex and Endurant; n = 173). The main outcome was the incidence of limb occlusion and severe limb stenosis (EIA related limb complications). The risk factors for EIA related limb complications were analysed and the midterm results between groups A and B compared. Fine–Gray generalisation of the proportional hazards model was used after propensity score matching to calculate the hazard ratio (HR). Results: One complication occurred in group A and 10 complications occurred in group B. The risk factors for EIA related limb complications for the entire group were a stent graft limb size ≤10 mm (HR 5.41; p =.01) and inclusion in group B (HR 14.9; p =.009). After propensity matching, group A (n = 159) was matched with group B (n = 159). The cumulative incidence function of EIA related limb complications at five years was 0.66% in group A and 7.8% in group B (HR 8.67; p =.039). Conclusion: Stent graft design can affect limb patency in EIA limb deployment. When EIA limb deployment is necessary for patients with a small EIA, such as Japanese patients, stent graft limbs made of a helical stent with ePTFE should be used to reduce the risk of limb occlusion.

AB - Objective/Background: It was hypothesised that a helical stent with expanded polytetrafluoroethylene (ePTFE) grafts could provide a preventive effect for external iliac artery (EIA) limb occlusion following endovascular aortic aneurysm repair (EVAR). Therefore, a post-hoc analysis of a Japanese multicentre database was conducted to assess the impact of the stent graft design on EIA limb occlusion rates. Methods: Patients who underwent EVAR with EIA limb deployment between 2008 and 2016 were evaluated. The stent graft limbs were divided into two groups: group A comprised stent graft limbs made of a helical stent with ePTFE grafts (Excluder; n = 255), and group B comprised stent graft limbs made of a Z stent with polyester grafts (Zenith, Flex and Endurant; n = 173). The main outcome was the incidence of limb occlusion and severe limb stenosis (EIA related limb complications). The risk factors for EIA related limb complications were analysed and the midterm results between groups A and B compared. Fine–Gray generalisation of the proportional hazards model was used after propensity score matching to calculate the hazard ratio (HR). Results: One complication occurred in group A and 10 complications occurred in group B. The risk factors for EIA related limb complications for the entire group were a stent graft limb size ≤10 mm (HR 5.41; p =.01) and inclusion in group B (HR 14.9; p =.009). After propensity matching, group A (n = 159) was matched with group B (n = 159). The cumulative incidence function of EIA related limb complications at five years was 0.66% in group A and 7.8% in group B (HR 8.67; p =.039). Conclusion: Stent graft design can affect limb patency in EIA limb deployment. When EIA limb deployment is necessary for patients with a small EIA, such as Japanese patients, stent graft limbs made of a helical stent with ePTFE should be used to reduce the risk of limb occlusion.

KW - Abdominal aortic aneurysm

KW - EIA limb occlusion

KW - Endovascular aortic aneurysm repair

KW - Japanese

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