Impaired autonomic nervous system in alcoholics assessed by heart rate variation

A. Yokoyama, T. Takagi, H. Ishii, Taro Muramatsu, J. Akai, Shinzo Kato, S. Hori, K. Maruyama, H. Kono, M. Tsuchiya

Research output: Contribution to journalArticle

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Abstract

The suppression of heart rate variation reflects cardiac autonomic nervous dysfunction and is known to be associated with a poor prognosis or sudden death in diabetic patients. We investigated consecutive changes in the heart rate variation in 51 alcoholics using the coefficient of variation of R-R interval (CV(RR)). To correct for age effects, a ratio of CV(RR) to the standard predicted value (CV(P)) was calculated. On the whole, CV(RR)/CV(P) was suppressed on admission and on the 7th day of abstinence and increased on the 30th day. However, alcoholics could be divided into two groups by their CV(RR)/CV(P) on the 30th day: one group with transient autonomic dysfunction whose CV(RR)/CV(P) was more than 0.8 (n = 32), and the other group with persistent autonomic dysfunction whose CV(RR)/CV(P) was less than 0.8 (n = 19). Withdrawal hypertension occurred more frequently (63% vs. 19%) and mean systolic pressure (159 ± 24 mmHg vs. 138 ± 17 mmHg) was higher in the latter group than in the former, suggesting that persistent autonomic damage might, at least in part, contribute to withdrawal hypertension. To investigate further the relationship between the persistent autonomic damage and other complications, the CV(RR)/CV(P) on the 30th day of abstinence was analyzed in an additional 85 alcoholics (total n = 136). Persistent suppression of the CV(RR)/CV(P) was more frequently found in alcoholics with leg paresthesia (64%, n = 22), the Wernicke-Korsakoff syndrome (73%, n = 11), or diabetes mellitus (69%, n = 68), than in alcoholics without these complications (31%, n = 35). This suggests that persistent autonomic dysfunction reflects damage in both the peripheral and the central autonomic nervous systems and is exacerbated by the complication of diabetes mellitus. The measurement of CV(RR) on the 30th day of abstinence is useful to evaluate persistent autonomic dysfunction in alcoholics.

Original languageEnglish
Pages (from-to)761-765
Number of pages5
JournalAlcoholism: Clinical and Experimental Research
Volume15
Issue number5
DOIs
Publication statusPublished - 1991

Fingerprint

Autonomic Nervous System
Neurology
Alcoholics
Medical problems
Heart Rate
Korsakoff Syndrome
Hypertension
Paresthesia
Diabetes Complications
Sudden Death
Leg
Diabetes Mellitus
Central Nervous System
Blood Pressure

Keywords

  • Alcoholism
  • Autonomic nervous dysfunction
  • Diabetes mellitus
  • Heart rate variation
  • Hypertension

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Impaired autonomic nervous system in alcoholics assessed by heart rate variation. / Yokoyama, A.; Takagi, T.; Ishii, H.; Muramatsu, Taro; Akai, J.; Kato, Shinzo; Hori, S.; Maruyama, K.; Kono, H.; Tsuchiya, M.

In: Alcoholism: Clinical and Experimental Research, Vol. 15, No. 5, 1991, p. 761-765.

Research output: Contribution to journalArticle

Yokoyama, A. ; Takagi, T. ; Ishii, H. ; Muramatsu, Taro ; Akai, J. ; Kato, Shinzo ; Hori, S. ; Maruyama, K. ; Kono, H. ; Tsuchiya, M. / Impaired autonomic nervous system in alcoholics assessed by heart rate variation. In: Alcoholism: Clinical and Experimental Research. 1991 ; Vol. 15, No. 5. pp. 761-765.
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AB - The suppression of heart rate variation reflects cardiac autonomic nervous dysfunction and is known to be associated with a poor prognosis or sudden death in diabetic patients. We investigated consecutive changes in the heart rate variation in 51 alcoholics using the coefficient of variation of R-R interval (CV(RR)). To correct for age effects, a ratio of CV(RR) to the standard predicted value (CV(P)) was calculated. On the whole, CV(RR)/CV(P) was suppressed on admission and on the 7th day of abstinence and increased on the 30th day. However, alcoholics could be divided into two groups by their CV(RR)/CV(P) on the 30th day: one group with transient autonomic dysfunction whose CV(RR)/CV(P) was more than 0.8 (n = 32), and the other group with persistent autonomic dysfunction whose CV(RR)/CV(P) was less than 0.8 (n = 19). Withdrawal hypertension occurred more frequently (63% vs. 19%) and mean systolic pressure (159 ± 24 mmHg vs. 138 ± 17 mmHg) was higher in the latter group than in the former, suggesting that persistent autonomic damage might, at least in part, contribute to withdrawal hypertension. To investigate further the relationship between the persistent autonomic damage and other complications, the CV(RR)/CV(P) on the 30th day of abstinence was analyzed in an additional 85 alcoholics (total n = 136). Persistent suppression of the CV(RR)/CV(P) was more frequently found in alcoholics with leg paresthesia (64%, n = 22), the Wernicke-Korsakoff syndrome (73%, n = 11), or diabetes mellitus (69%, n = 68), than in alcoholics without these complications (31%, n = 35). This suggests that persistent autonomic dysfunction reflects damage in both the peripheral and the central autonomic nervous systems and is exacerbated by the complication of diabetes mellitus. The measurement of CV(RR) on the 30th day of abstinence is useful to evaluate persistent autonomic dysfunction in alcoholics.

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