Impaired guanosine 3',5'-cyclic phosphate production in severe pregnancy-induced hypertension with high plasma levels of atrial and brain natriuretic peptides

Hiroaki Itoh, Norimasa Sagawa, Hidetaka Nanno, Takahide Mori, Masashi Mukoyama, Hiroshi Itoh, Kazuwa Nakao

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To investigate the activation of particulate guanylate cyclase in pregnant women with pregnancy-induced hypertension (PIH), plasma levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and guanosine 3',5'-cyclic phosphate (cGMP) were measured by radioimmunoassays specific to each substance. Ten normal nonpregnant women, and 30 normal pregnant women, 17 pregnant women with mild PIH and 11 pregnant women with severe PIH in the third trimester were included in this retrospective observational study. The diagnosis and classification of hypertension were carried out according to the technical bulletin (No. 91) of the American College of Obstetricians and Gynecologists. In the pregnant women with mild PIH, plasma cGMP levels as well as ANP and BNP levels were significantly (P<0.05) higher than those in gestational age-matched normal pregnant or nonpregnant women. But in the pregnant women with severe PIH, plasma cGMP levels were significantly lower than those in pregnant women with mild PIH (P<0.05), although plasma ANP and BNP levels were higher than those in pregnant women with mild PIH.

Original languageEnglish
Pages (from-to)389-393
Number of pages5
JournalEndocrine journal
Issue number3
Publication statusPublished - 1997 Jun



  • Atrial natriuretic peptide
  • Brain natriuretic peptide
  • Guanosine 3',5'- cyclic phosphate
  • Pregnancy-induced hypertension

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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