TY - JOUR
T1 - Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis
AU - Nakajima, Takayuki
AU - Yokota, Takashi
AU - Shingu, Yasushige
AU - Yamada, Akira
AU - Iba, Yutaka
AU - Ujihira, Kosuke
AU - Wakasa, Satoru
AU - Ooka, Tomonori
AU - Takada, Shingo
AU - Shirakawa, Ryosuke
AU - Katayama, Takashi
AU - Furihata, Takaaki
AU - Fukushima, Arata
AU - Matsuoka, Ryosuke
AU - Nishihara, Hiroshi
AU - Dela, Flemming
AU - Nakanishi, Katsuhiko
AU - Matsui, Yoshiro
AU - Kinugawa, Shintaro
N1 - Funding Information:
This work was supported by the grants from Japanese Grants-In-Aid for Scientific Research (15K09115, 26750331, 17H04758), the Mochida Memorial Foundation for Medical and Pharmaceutical Research, the Nakatomi Foundation, the Japan Foundation for Applied Enzymology, a Hokkaido Heart Association Grant for Research, the Northern Advancement Center for Science & Technology, the Japan Heart Foundation, an Astellas Grant for Research on Atherosclerosis Update, the MSD Life Science Foundation, the Uehara Memorial Foundation, and the Center of Innovation Program from Japan Science and Technology Agency. We thank Koji Ishikawa, Naoya Kakutani, Akemi Doda, Mami Sato, and Kota Ono for their technical assistance.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role of EAT mitochondria in coronary artery disease (CAD) has not been established. We investigated the association between EAT mitochondrial respiratory capacity, adiponectin concentration in the EAT, and coronary atherosclerosis. EAT samples were obtained from 25 patients who underwent elective cardiac surgery. Based on the coronary angiographycal findings, the patients were divided into two groups; coronary artery disease (CAD; n = 14) and non-CAD (n = 11) groups. The mitochondrial respiratory capacities including oxidative phosphorylation (OXPHOS) capacity with non-fatty acid (complex I and complex I + II-linked) substrates and fatty acids in the EAT were significantly lowered in CAD patients. The EAT mitochondrial OXPHOS capacities had a close and inverse correlation with the severity of coronary artery stenosis evaluated by the Gensini score. Intriguingly, the protein level of adiponectin, an anti-atherogenic adipokine, in the EAT was significantly reduced in CAD patients, and it was positively correlated with the mitochondrial OXPHOS capacities in the EAT and inversely correlated with the Gensini score. Our study showed that impaired mitochondrial OXPHOS capacity in the EAT was closely linked to decreased concentration of adiponectin in the EAT and severity of coronary atherosclerosis.
AB - Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role of EAT mitochondria in coronary artery disease (CAD) has not been established. We investigated the association between EAT mitochondrial respiratory capacity, adiponectin concentration in the EAT, and coronary atherosclerosis. EAT samples were obtained from 25 patients who underwent elective cardiac surgery. Based on the coronary angiographycal findings, the patients were divided into two groups; coronary artery disease (CAD; n = 14) and non-CAD (n = 11) groups. The mitochondrial respiratory capacities including oxidative phosphorylation (OXPHOS) capacity with non-fatty acid (complex I and complex I + II-linked) substrates and fatty acids in the EAT were significantly lowered in CAD patients. The EAT mitochondrial OXPHOS capacities had a close and inverse correlation with the severity of coronary artery stenosis evaluated by the Gensini score. Intriguingly, the protein level of adiponectin, an anti-atherogenic adipokine, in the EAT was significantly reduced in CAD patients, and it was positively correlated with the mitochondrial OXPHOS capacities in the EAT and inversely correlated with the Gensini score. Our study showed that impaired mitochondrial OXPHOS capacity in the EAT was closely linked to decreased concentration of adiponectin in the EAT and severity of coronary atherosclerosis.
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U2 - 10.1038/s41598-019-40419-7
DO - 10.1038/s41598-019-40419-7
M3 - Article
C2 - 30837669
AN - SCOPUS:85062571865
SN - 2045-2322
VL - 9
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 3535
ER -