Impaired spatial and contextual memory formation in galectin-1 deficient mice

Masanori Sakaguchi, Maithe Arruda-Carvalho, Na Hyea Kang, Yoichi Imaizumi, Françoise Poirier, Hideyuki Okano, Paul W. Frankland

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Galectins are a 15 member family of carbohydrate-binding proteins that have been implicated in cancer, immunity, inflammation and development. While galectins are expressed in the central nervous system, little is known about their function in the adult brain. Previously we have shown that galectin-1 (gal-1) is expressed in the adult hippocampus, and, in particular, in putative neural stem cells in the subgranular zone. To evaluate how gal-1 might contribute to hippocampal memory function here we studied galectin-1 null mutant (gal-1-/-) mice. Compared to their wildtype littermate controls, gal-1-/- mice exhibited impaired spatial learning in the water maze and contextual fear learning. Interestingly, tone fear conditioning was normal in gal-1-/- mice suggesting that loss of gal-1 might especially impact hippocampal learning and memory. Furthermore, gal-1-/- mice exhibited normal motor function, emotion and sensory processing in a battery of other behavioral tests, suggesting that non-mnemonic performance deficits are unlikely to account for the spatial and contextual learning deficits. Together, these data reveal a role for galectin-carbohydrate signalling in hippocampal memory function.

Original languageEnglish
Article number33
JournalMolecular Brain
Volume4
Issue number1
DOIs
Publication statusPublished - 2011

Fingerprint

Galectin 1
Galectins
Fear
Learning
Neural Stem Cells
Spatial Memory
Immunity
Hippocampus
Emotions
Central Nervous System
Carbohydrates
Inflammation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Biology

Cite this

Sakaguchi, M., Arruda-Carvalho, M., Kang, N. H., Imaizumi, Y., Poirier, F., Okano, H., & Frankland, P. W. (2011). Impaired spatial and contextual memory formation in galectin-1 deficient mice. Molecular Brain, 4(1), [33]. https://doi.org/10.1186/1756-6606-4-33

Impaired spatial and contextual memory formation in galectin-1 deficient mice. / Sakaguchi, Masanori; Arruda-Carvalho, Maithe; Kang, Na Hyea; Imaizumi, Yoichi; Poirier, Françoise; Okano, Hideyuki; Frankland, Paul W.

In: Molecular Brain, Vol. 4, No. 1, 33, 2011.

Research output: Contribution to journalArticle

Sakaguchi, M, Arruda-Carvalho, M, Kang, NH, Imaizumi, Y, Poirier, F, Okano, H & Frankland, PW 2011, 'Impaired spatial and contextual memory formation in galectin-1 deficient mice', Molecular Brain, vol. 4, no. 1, 33. https://doi.org/10.1186/1756-6606-4-33
Sakaguchi, Masanori ; Arruda-Carvalho, Maithe ; Kang, Na Hyea ; Imaizumi, Yoichi ; Poirier, Françoise ; Okano, Hideyuki ; Frankland, Paul W. / Impaired spatial and contextual memory formation in galectin-1 deficient mice. In: Molecular Brain. 2011 ; Vol. 4, No. 1.
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