Impaired urinary water excretion in a three-generation family

Y. Tanaka, K. Sugita, T. Saito, K. Muroya, S. E. Ishikawa, M. Awazu, T. Ogata

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We report on a three-generation family (daughter, mother, and maternal grandmother) with a syndrome of inappropriate secretion of antidiuretic hormone (SIADH)-like condition in the absence of inappropriate ADH secretion. In the three females, a water load test showed severely reduced urinary water excretion, with the ratio of urine volume to the loaded water being 10-33% (normal value: 70.2±7.8%). Urinary AQP2 excretion was normal, as was the DNA sequence of AVPR2 and AQP2. The results suggest the presence of a new dominantly inherited disorder for tubular water resorption.

Original languageEnglish
Pages (from-to)820-822
Number of pages3
JournalPediatric Nephrology
Volume16
Issue number10
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Water
Mothers
Inappropriate ADH Syndrome
Nuclear Family
Reference Values
Urine
Grandparents

Keywords

  • Active water resorption
  • AQP2
  • AVP
  • Dominant disorder
  • SIADH

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Tanaka, Y., Sugita, K., Saito, T., Muroya, K., Ishikawa, S. E., Awazu, M., & Ogata, T. (2001). Impaired urinary water excretion in a three-generation family. Pediatric Nephrology, 16(10), 820-822. https://doi.org/10.1007/s004670100663

Impaired urinary water excretion in a three-generation family. / Tanaka, Y.; Sugita, K.; Saito, T.; Muroya, K.; Ishikawa, S. E.; Awazu, M.; Ogata, T.

In: Pediatric Nephrology, Vol. 16, No. 10, 2001, p. 820-822.

Research output: Contribution to journalArticle

Tanaka, Y, Sugita, K, Saito, T, Muroya, K, Ishikawa, SE, Awazu, M & Ogata, T 2001, 'Impaired urinary water excretion in a three-generation family', Pediatric Nephrology, vol. 16, no. 10, pp. 820-822. https://doi.org/10.1007/s004670100663
Tanaka Y, Sugita K, Saito T, Muroya K, Ishikawa SE, Awazu M et al. Impaired urinary water excretion in a three-generation family. Pediatric Nephrology. 2001;16(10):820-822. https://doi.org/10.1007/s004670100663
Tanaka, Y. ; Sugita, K. ; Saito, T. ; Muroya, K. ; Ishikawa, S. E. ; Awazu, M. ; Ogata, T. / Impaired urinary water excretion in a three-generation family. In: Pediatric Nephrology. 2001 ; Vol. 16, No. 10. pp. 820-822.
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