Impaired urinary water excretion in a three-generation family

Y. Tanaka, K. Sugita, T. Saito, K. Muroya, S. E. Ishikawa, M. Awazu, T. Ogata

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We report on a three-generation family (daughter, mother, and maternal grandmother) with a syndrome of inappropriate secretion of antidiuretic hormone (SIADH)-like condition in the absence of inappropriate ADH secretion. In the three females, a water load test showed severely reduced urinary water excretion, with the ratio of urine volume to the loaded water being 10-33% (normal value: 70.2±7.8%). Urinary AQP2 excretion was normal, as was the DNA sequence of AVPR2 and AQP2. The results suggest the presence of a new dominantly inherited disorder for tubular water resorption.

Original languageEnglish
Pages (from-to)820-822
Number of pages3
JournalPediatric Nephrology
Issue number10
Publication statusPublished - 2001
Externally publishedYes


  • AQP2
  • AVP
  • Active water resorption
  • Dominant disorder

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology


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