Impaired urinary water excretion in a three-generation family

Y. Tanaka, K. Sugita, T. Saito, K. Muroya, S. E. Ishikawa, M. Awazu, T. Ogata

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Abstract

We report on a three-generation family (daughter, mother, and maternal grandmother) with a syndrome of inappropriate secretion of antidiuretic hormone (SIADH)-like condition in the absence of inappropriate ADH secretion. In the three females, a water load test showed severely reduced urinary water excretion, with the ratio of urine volume to the loaded water being 10-33% (normal value: 70.2±7.8%). Urinary AQP2 excretion was normal, as was the DNA sequence of AVPR2 and AQP2. The results suggest the presence of a new dominantly inherited disorder for tubular water resorption.

Original languageEnglish
Pages (from-to)820-822
Number of pages3
JournalPediatric Nephrology
Volume16
Issue number10
DOIs
Publication statusPublished - 2001 Jan 1

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Keywords

  • AQP2
  • AVP
  • Active water resorption
  • Dominant disorder
  • SIADH

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Tanaka, Y., Sugita, K., Saito, T., Muroya, K., Ishikawa, S. E., Awazu, M., & Ogata, T. (2001). Impaired urinary water excretion in a three-generation family. Pediatric Nephrology, 16(10), 820-822. https://doi.org/10.1007/s004670100663