Impaired urinary water excretion in a three-generation family

Y. Tanaka; K. Sugita; T. Saito; K. Muroya; S. E. Ishikawa; M. Awazu; T. Ogata

doi:10.1007/s004670100663

Impaired urinary water excretion in a three-generation family

Y. Tanaka, K. Sugita, T. Saito, K. Muroya, S. E. Ishikawa, M. Awazu, T. Ogata

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We report on a three-generation family (daughter, mother, and maternal grandmother) with a syndrome of inappropriate secretion of antidiuretic hormone (SIADH)-like condition in the absence of inappropriate ADH secretion. In the three females, a water load test showed severely reduced urinary water excretion, with the ratio of urine volume to the loaded water being 10-33% (normal value: 70.2±7.8%). Urinary AQP2 excretion was normal, as was the DNA sequence of AVPR2 and AQP2. The results suggest the presence of a new dominantly inherited disorder for tubular water resorption.

Original language	English
Pages (from-to)	820-822
Number of pages	3
Journal	Pediatric Nephrology
Volume	16
Issue number	10
DOIs	https://doi.org/10.1007/s004670100663
Publication status	Published - 2001
Externally published	Yes

Keywords

AQP2
AVP
Active water resorption
Dominant disorder
SIADH

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Nephrology

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10.1007/s004670100663

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title = "Impaired urinary water excretion in a three-generation family",

abstract = "We report on a three-generation family (daughter, mother, and maternal grandmother) with a syndrome of inappropriate secretion of antidiuretic hormone (SIADH)-like condition in the absence of inappropriate ADH secretion. In the three females, a water load test showed severely reduced urinary water excretion, with the ratio of urine volume to the loaded water being 10-33% (normal value: 70.2±7.8%). Urinary AQP2 excretion was normal, as was the DNA sequence of AVPR2 and AQP2. The results suggest the presence of a new dominantly inherited disorder for tubular water resorption.",

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T1 - Impaired urinary water excretion in a three-generation family

AU - Tanaka, Y.

AU - Sugita, K.

AU - Saito, T.

AU - Muroya, K.

AU - Ishikawa, S. E.

AU - Awazu, M.

AU - Ogata, T.

PY - 2001

Y1 - 2001

N2 - We report on a three-generation family (daughter, mother, and maternal grandmother) with a syndrome of inappropriate secretion of antidiuretic hormone (SIADH)-like condition in the absence of inappropriate ADH secretion. In the three females, a water load test showed severely reduced urinary water excretion, with the ratio of urine volume to the loaded water being 10-33% (normal value: 70.2±7.8%). Urinary AQP2 excretion was normal, as was the DNA sequence of AVPR2 and AQP2. The results suggest the presence of a new dominantly inherited disorder for tubular water resorption.

AB - We report on a three-generation family (daughter, mother, and maternal grandmother) with a syndrome of inappropriate secretion of antidiuretic hormone (SIADH)-like condition in the absence of inappropriate ADH secretion. In the three females, a water load test showed severely reduced urinary water excretion, with the ratio of urine volume to the loaded water being 10-33% (normal value: 70.2±7.8%). Urinary AQP2 excretion was normal, as was the DNA sequence of AVPR2 and AQP2. The results suggest the presence of a new dominantly inherited disorder for tubular water resorption.

KW - AQP2

KW - AVP

KW - Active water resorption

KW - Dominant disorder

KW - SIADH

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Impaired urinary water excretion in a three-generation family

Abstract

Keywords

ASJC Scopus subject areas

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