Impairment of decision-making cognition in a case of frontotemporal lobar degeneration (FTLD) presenting with pathologic gambling and hoarding as the initial symptoms

Shutaro Nakaaki, Yoshie Murata, Junko Sato, Yoshihiro Shinagawa, Jin Hongo, Hiroshi Tatsumi, Masaru Mimura, Toshi A. Furukawa

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

OBJECTIVE: The aim of this study was to use the Iowa Gambling Task (IGT) to examine decision-making cognition in a patient with mild frontal variant of frontotemporal dementia (fv-FTD). BACKGROUND: Although fv-FTD may present with bizarre and dramatic behavioral changes, traditional executive tasks are sometimes preserved in patients with mild fv-FTD. Some evidence suggests that tasks assessing decision-making cognition, such as the IGT, may be sensitive to detect cognitive dysfunction in patients with mild fv-FTD. Here, we report a patient with fv-FTD who presented with bizarre behavior including hoarding, pathologic gambling, and abnormal sexual behavior. METHODS: A 54-year-old man who had been diagnosed as having fv-FTD was examined using a behavioral assessment, a wide range of neuropsychologic tasks, and the IGT. Brain magnetic resonance imaging and brain Tc-ethylcysteinate dimer single-photon emission computed tomography examinations were also performed. RESULTS: Although the patient's cognitive abilities were almost fully preserved for a number of traditional neuropsychologic tasks (memory, executive function), the IGT suggested that his decision-making cognition was impaired. The Tc-ethylcysteinate dimer single-photon emission computed tomography examination revealed hypometabolism in bilateral medial frontal and orbitofrontal regions of the cerebral cortex, and also in the cingulate gyri. CONCLUSIONS: Our findings suggest that the IGT may be a sensitive tool for assessing patients with mild fv-FTD before the development of severe dementia. We speculate that the deficit in decision-making cognition observed in the present case was associated with hypometabolism in the neural networks of the frontal lobe and involving both the bilateral medial frontal and orbitofrontal regions of the cerebral cortex.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalCognitive and Behavioral Neurology
Volume20
Issue number2
DOIs
Publication statusPublished - 2007 Jun
Externally publishedYes

Fingerprint

Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Gambling
Cognition
Decision Making
Prefrontal Cortex
Single-Photon Emission-Computed Tomography
Cerebral Cortex
Aptitude
Gyrus Cinguli
Executive Function
Brain
Frontal Lobe
Hoarding
Sexual Behavior
Dementia
Magnetic Resonance Imaging

Keywords

  • Decision-making cognition
  • Frontotemporal lobar degeneration
  • Orbitofrontal area
  • The Iowa Gambling Task

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Behavioral Neuroscience
  • Cognitive Neuroscience

Cite this

Impairment of decision-making cognition in a case of frontotemporal lobar degeneration (FTLD) presenting with pathologic gambling and hoarding as the initial symptoms. / Nakaaki, Shutaro; Murata, Yoshie; Sato, Junko; Shinagawa, Yoshihiro; Hongo, Jin; Tatsumi, Hiroshi; Mimura, Masaru; Furukawa, Toshi A.

In: Cognitive and Behavioral Neurology, Vol. 20, No. 2, 06.2007, p. 121-125.

Research output: Contribution to journalArticle

Nakaaki, Shutaro ; Murata, Yoshie ; Sato, Junko ; Shinagawa, Yoshihiro ; Hongo, Jin ; Tatsumi, Hiroshi ; Mimura, Masaru ; Furukawa, Toshi A. / Impairment of decision-making cognition in a case of frontotemporal lobar degeneration (FTLD) presenting with pathologic gambling and hoarding as the initial symptoms. In: Cognitive and Behavioral Neurology. 2007 ; Vol. 20, No. 2. pp. 121-125.
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AU - Sato, Junko

AU - Shinagawa, Yoshihiro

AU - Hongo, Jin

AU - Tatsumi, Hiroshi

AU - Mimura, Masaru

AU - Furukawa, Toshi A.

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