TY - JOUR
T1 - Impairment of nasal airway under intermittent hypoxia during growth period in rats
AU - Kuma, Yoichiro
AU - Usumi-Fujita, Risa
AU - Hosomichi, Jun
AU - Oishi, Shuji
AU - Maeda, Hideyuki
AU - Nagai, Hisashi
AU - Shimizu, Yasuhiro
AU - Kaneko, Sawa
AU - Shitano, Chisa
AU - Suzuki, Jun Ichi
AU - Yoshida, Ken Ichi
AU - Ono, Takashi
N1 - Funding Information:
This study was financially supported in part by Grants-in-Aid for Scientific Research ( 23249038 , 25463170 ) from the Japanese Ministry of Education, Culture, Sports, Science and Technology .
PY - 2014/11
Y1 - 2014/11
N2 - Objective To clarify the influences of intermittent hypoxia (IH) on the growth and development of the midfacial area, including the nasal cavity, in growing rats. Design Seven-week-old male Sprague-Dawley rats were divided into two groups: the experimental group (n = 5), which was exposed to IH for 8 h during light periods at a rate of 20 cycles/h (nadir, 4% O2 to peak, 21% O2 with 0% CO2), and the control group (n = 5), which was exposed to room air. After 3 weeks, the maxillofacial structures in both groups were evaluated with respect to the height, width, length, surface area, cross-sectional area, and volume of the nasal cavity using soft X-ray and micro-CT. Results The experimental group showed a significantly smaller cross-sectional area and volume than did the control group. The surface area exhibited no significant differences between the two groups, although it tended to be smaller in the experimental group than in the control group. The nasal volume divided by the length of the tibia (for comparison with whole-body growth) was significantly smaller in the experimental group than in the control group. Conclusions These data suggest that IH exposure suppresses growth and development of the nasal cavity and may result in nasal breathing disturbance.
AB - Objective To clarify the influences of intermittent hypoxia (IH) on the growth and development of the midfacial area, including the nasal cavity, in growing rats. Design Seven-week-old male Sprague-Dawley rats were divided into two groups: the experimental group (n = 5), which was exposed to IH for 8 h during light periods at a rate of 20 cycles/h (nadir, 4% O2 to peak, 21% O2 with 0% CO2), and the control group (n = 5), which was exposed to room air. After 3 weeks, the maxillofacial structures in both groups were evaluated with respect to the height, width, length, surface area, cross-sectional area, and volume of the nasal cavity using soft X-ray and micro-CT. Results The experimental group showed a significantly smaller cross-sectional area and volume than did the control group. The surface area exhibited no significant differences between the two groups, although it tended to be smaller in the experimental group than in the control group. The nasal volume divided by the length of the tibia (for comparison with whole-body growth) was significantly smaller in the experimental group than in the control group. Conclusions These data suggest that IH exposure suppresses growth and development of the nasal cavity and may result in nasal breathing disturbance.
KW - Intermittent hypoxia
KW - Micro-CT
KW - Nasomaxillary complex
KW - Paediatric obstructive sleep apnoea
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U2 - 10.1016/j.archoralbio.2014.06.005
DO - 10.1016/j.archoralbio.2014.06.005
M3 - Article
C2 - 25073088
AN - SCOPUS:84904978247
VL - 59
SP - 1139
EP - 1145
JO - Archives of Oral Biology
JF - Archives of Oral Biology
SN - 0003-9969
IS - 11
ER -