Implantable hydrogel microfiber encapsulating pancreatic beta-cells for diabetes treatment

S. Sugimoto, Y. J. Heo, Hiroaki Onoe, T. Okitsu, H. Kotera, S. Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

This paper describes implantable hydrogel microfibers encapsulating living pancreatic beta-cells for diabetes treatment. The structure of microfiber has a potential not only to implant but also to remove the pancreatic beta-cells encapsulated in the microfiber, indicating that our microfiber can be a cartridge-type device to regulate blood glucose. We successfully validated the potency of our microfibers by implanting them into chemically induced diabetic mice and normalizing their blood glucose. We believe that our method to encapsulate pancreatic beta-cells in the microfibers could be useful for cell-based medicine targeted to diabetes mellitus.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages1248-1250
Number of pages3
Volume2
Publication statusPublished - 2011
Externally publishedYes
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2011 Oct 22011 Oct 6

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period11/10/211/10/6

Fingerprint

Medical problems
Hydrogels
Glucose
Blood
Medicine

Keywords

  • Cell encapsulation
  • Diabetes treatment
  • Pancreatic beta-cells
  • Tissue engineering

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Sugimoto, S., Heo, Y. J., Onoe, H., Okitsu, T., Kotera, H., & Takeuchi, S. (2011). Implantable hydrogel microfiber encapsulating pancreatic beta-cells for diabetes treatment. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (Vol. 2, pp. 1248-1250)

Implantable hydrogel microfiber encapsulating pancreatic beta-cells for diabetes treatment. / Sugimoto, S.; Heo, Y. J.; Onoe, Hiroaki; Okitsu, T.; Kotera, H.; Takeuchi, S.

15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 2 2011. p. 1248-1250.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sugimoto, S, Heo, YJ, Onoe, H, Okitsu, T, Kotera, H & Takeuchi, S 2011, Implantable hydrogel microfiber encapsulating pancreatic beta-cells for diabetes treatment. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. vol. 2, pp. 1248-1250, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, Seattle, WA, United States, 11/10/2.
Sugimoto S, Heo YJ, Onoe H, Okitsu T, Kotera H, Takeuchi S. Implantable hydrogel microfiber encapsulating pancreatic beta-cells for diabetes treatment. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 2. 2011. p. 1248-1250
Sugimoto, S. ; Heo, Y. J. ; Onoe, Hiroaki ; Okitsu, T. ; Kotera, H. ; Takeuchi, S. / Implantable hydrogel microfiber encapsulating pancreatic beta-cells for diabetes treatment. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 2 2011. pp. 1248-1250
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