Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia

Tsutomu Sasaki, Kazuo Kitagawa, Shiro Sugiura, Emi Omura-Matsuoka, Shigeru Tanaka, Yoshiki Yagita, Hideyuki Okano, Masayasu Matsumoto, Masatsugu Hori

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Global ischemia promotes neurogenesis in the dentate gyrus of the adult mouse hippocampus. Cyclooxygenase (COX)-2, the principal isoenzyme in the brain, modulates inflammation, glutamate-mediated cytotoxicity, and synaptic plasticity. We demonstrated that delayed treatment with different classes of COX inhibitor significantly blunted enhancement of dentate gyrus proliferation of neural progenitor cells after ischemia. COX-2 immunore-activity was observed in both neurons and astrocytes in the dentate gyrus, but not in neural progenitor cells in the subgranular zone. Moreover, in the postischemic dentate gyrus of heterozygous and homozygous COX-2 knock-out mice, proliferating bromodeoxyuridine-positive cells were significantly fewer than in wild-type littermates. These results demonstrate that COX-2 is an important modulator in enhancement of proliferation of neural progenitor cells after ischemia.

Original languageEnglish
Pages (from-to)461-471
Number of pages11
JournalJournal of neuroscience research
Volume72
Issue number4
DOIs
Publication statusPublished - 2003 May 15

Keywords

  • COX-2
  • Hippocampus
  • Musashi-1
  • Neurogenesis
  • Neuronal progenitor

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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