TY - JOUR
T1 - Important concepts for treating ocular surface and tear disorders
AU - Tseng, S. C.G.
AU - Tsubota, K.
N1 - Funding Information:
Concept 5: Ocular Surface Epithelial Cell Function Is Supported by Stromal Fibroblasts and Matrix
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - PURPOSE: To outline important concepts for treating ocular surface and tear disorders. METHOD: A review was conducted of recently published findings. RESULTS: Five concepts were delineated: ocular surface health is ensured by a close relationship between ocular surface epithelia and the preocular tear film; a stable tear film is inherently maintained by external adnexae; the intact protective mechanism is controlled by effective neuroanatomic integration; corneal epithelial stem cells are located at the corneoscleral limbus; and ocular surface epithelial cell function is supported by stromal fibroblasts and matrix. CONCLUSIONS: These concepts stress that ocular surface epithelia and the preocular tear film function as a unit and, furthermore, that several corneal and external diseases can be categorized as ocular surface and tear disorders. These concepts also help one formulate unified diagnostic and therapeutic strategies for management of these diseases.
AB - PURPOSE: To outline important concepts for treating ocular surface and tear disorders. METHOD: A review was conducted of recently published findings. RESULTS: Five concepts were delineated: ocular surface health is ensured by a close relationship between ocular surface epithelia and the preocular tear film; a stable tear film is inherently maintained by external adnexae; the intact protective mechanism is controlled by effective neuroanatomic integration; corneal epithelial stem cells are located at the corneoscleral limbus; and ocular surface epithelial cell function is supported by stromal fibroblasts and matrix. CONCLUSIONS: These concepts stress that ocular surface epithelia and the preocular tear film function as a unit and, furthermore, that several corneal and external diseases can be categorized as ocular surface and tear disorders. These concepts also help one formulate unified diagnostic and therapeutic strategies for management of these diseases.
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U2 - 10.1016/S0002-9394(14)71700-3
DO - 10.1016/S0002-9394(14)71700-3
M3 - Article
C2 - 9402829
AN - SCOPUS:0030817272
VL - 124
SP - 825
EP - 835
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 6
ER -