Improved apparatus for solid-liquid multi-stage counter-current extraction

Kayoko Tahara, Yoshihiro Abe, Setsuro Sugata, Hideyuki Nishizawa, Takashi Nishikawa, Hiroshi Suzuki, Makoto Takeuchi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An improved apparatus for solid-liquid multi-stage counter-current extraction (SLME) was developed. The apparatus has a set of 24 extraction vessels. Each extraction vessel unit is composed of a piston-cylinder in which the solid phase is placed, and a cup-cylinder in which the liquid phase is set. Of the 24 extraction vessels, 20 were used for the separation stage, and the other 4 were used for the back-extraction stage. (±)-Troger's base was selected as a racemic model compound for the continuous enantioseparation by the apparatus, and a cellulose derivative was used as the chiral separator. After 50 cycles of the operation (in 9h), 0.1g of (-)-enantiomer (85% in purity) was recovered from the solid phase by back-extraction with ethanol, whereas 1.1g of (+)-isomer (75% in purity) was collected from the liquid phase (ethanol).

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalJournal of Chromatography A
Volume1017
Issue number1-2
DOIs
Publication statusPublished - 2003 Oct 31

Keywords

  • Counter-current extraction
  • Enantiomer separation
  • Extraction methods
  • Instrumentation
  • True moving beds
  • Tröger's base

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Improved apparatus for solid-liquid multi-stage counter-current extraction'. Together they form a unique fingerprint.

  • Cite this

    Tahara, K., Abe, Y., Sugata, S., Nishizawa, H., Nishikawa, T., Suzuki, H., & Takeuchi, M. (2003). Improved apparatus for solid-liquid multi-stage counter-current extraction. Journal of Chromatography A, 1017(1-2), 63-69. https://doi.org/10.1016/j.chroma.2003.08.013