Improved apparatus for solid-liquid multi-stage counter-current extraction

Kayoko Tahara, Yoshihiro Abe, Setsuro Sugata, Hideyuki Nishizawa, Takashi Nishikawa, Hiroshi Suzuki, Makoto Takeuchi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


An improved apparatus for solid-liquid multi-stage counter-current extraction (SLME) was developed. The apparatus has a set of 24 extraction vessels. Each extraction vessel unit is composed of a piston-cylinder in which the solid phase is placed, and a cup-cylinder in which the liquid phase is set. Of the 24 extraction vessels, 20 were used for the separation stage, and the other 4 were used for the back-extraction stage. (±)-Troger's base was selected as a racemic model compound for the continuous enantioseparation by the apparatus, and a cellulose derivative was used as the chiral separator. After 50 cycles of the operation (in 9h), 0.1g of (-)-enantiomer (85% in purity) was recovered from the solid phase by back-extraction with ethanol, whereas 1.1g of (+)-isomer (75% in purity) was collected from the liquid phase (ethanol).

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalJournal of Chromatography A
Issue number1-2
Publication statusPublished - 2003 Oct 31


  • Counter-current extraction
  • Enantiomer separation
  • Extraction methods
  • Instrumentation
  • True moving beds
  • Tröger's base

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry


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