Improved apparatus for solid-liquid multi-stage counter-current extraction

Kayoko Tahara; Yoshihiro Abe; Setsuro Sugata; Hideyuki Nishizawa; Takashi Nishikawa; Hiroshi Suzuki; Makoto Takeuchi

doi:10.1016/j.chroma.2003.08.013

Improved apparatus for solid-liquid multi-stage counter-current extraction

Kayoko Tahara, Yoshihiro Abe, Setsuro Sugata, Hideyuki Nishizawa, Takashi Nishikawa, Hiroshi Suzuki, Makoto Takeuchi

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

An improved apparatus for solid-liquid multi-stage counter-current extraction (SLME) was developed. The apparatus has a set of 24 extraction vessels. Each extraction vessel unit is composed of a piston-cylinder in which the solid phase is placed, and a cup-cylinder in which the liquid phase is set. Of the 24 extraction vessels, 20 were used for the separation stage, and the other 4 were used for the back-extraction stage. (±)-Troger's base was selected as a racemic model compound for the continuous enantioseparation by the apparatus, and a cellulose derivative was used as the chiral separator. After 50 cycles of the operation (in 9h), 0.1g of (-)-enantiomer (85% in purity) was recovered from the solid phase by back-extraction with ethanol, whereas 1.1g of (+)-isomer (75% in purity) was collected from the liquid phase (ethanol).

Original language	English
Pages (from-to)	63-69
Number of pages	7
Journal	Journal of Chromatography A
Volume	1017
Issue number	1-2
DOIs	https://doi.org/10.1016/j.chroma.2003.08.013
Publication status	Published - 2003 Oct 31

Keywords

Counter-current extraction
Enantiomer separation
Extraction methods
Instrumentation
True moving beds
Tröger's base

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Organic Chemistry

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10.1016/j.chroma.2003.08.013

Cite this

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title = "Improved apparatus for solid-liquid multi-stage counter-current extraction",

abstract = "An improved apparatus for solid-liquid multi-stage counter-current extraction (SLME) was developed. The apparatus has a set of 24 extraction vessels. Each extraction vessel unit is composed of a piston-cylinder in which the solid phase is placed, and a cup-cylinder in which the liquid phase is set. Of the 24 extraction vessels, 20 were used for the separation stage, and the other 4 were used for the back-extraction stage. (±)-Troger's base was selected as a racemic model compound for the continuous enantioseparation by the apparatus, and a cellulose derivative was used as the chiral separator. After 50 cycles of the operation (in 9h), 0.1g of (-)-enantiomer (85% in purity) was recovered from the solid phase by back-extraction with ethanol, whereas 1.1g of (+)-isomer (75% in purity) was collected from the liquid phase (ethanol).",

keywords = "Counter-current extraction, Enantiomer separation, Extraction methods, Instrumentation, True moving beds, Tr{\"o}ger's base",

author = "Kayoko Tahara and Yoshihiro Abe and Setsuro Sugata and Hideyuki Nishizawa and Takashi Nishikawa and Hiroshi Suzuki and Makoto Takeuchi",

year = "2003",

month = oct,

day = "31",

doi = "10.1016/j.chroma.2003.08.013",

language = "English",

volume = "1017",

pages = "63--69",

journal = "Journal of Chromatography A",

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T1 - Improved apparatus for solid-liquid multi-stage counter-current extraction

AU - Tahara, Kayoko

AU - Abe, Yoshihiro

AU - Sugata, Setsuro

AU - Nishizawa, Hideyuki

AU - Nishikawa, Takashi

AU - Suzuki, Hiroshi

AU - Takeuchi, Makoto

PY - 2003/10/31

Y1 - 2003/10/31

N2 - An improved apparatus for solid-liquid multi-stage counter-current extraction (SLME) was developed. The apparatus has a set of 24 extraction vessels. Each extraction vessel unit is composed of a piston-cylinder in which the solid phase is placed, and a cup-cylinder in which the liquid phase is set. Of the 24 extraction vessels, 20 were used for the separation stage, and the other 4 were used for the back-extraction stage. (±)-Troger's base was selected as a racemic model compound for the continuous enantioseparation by the apparatus, and a cellulose derivative was used as the chiral separator. After 50 cycles of the operation (in 9h), 0.1g of (-)-enantiomer (85% in purity) was recovered from the solid phase by back-extraction with ethanol, whereas 1.1g of (+)-isomer (75% in purity) was collected from the liquid phase (ethanol).

AB - An improved apparatus for solid-liquid multi-stage counter-current extraction (SLME) was developed. The apparatus has a set of 24 extraction vessels. Each extraction vessel unit is composed of a piston-cylinder in which the solid phase is placed, and a cup-cylinder in which the liquid phase is set. Of the 24 extraction vessels, 20 were used for the separation stage, and the other 4 were used for the back-extraction stage. (±)-Troger's base was selected as a racemic model compound for the continuous enantioseparation by the apparatus, and a cellulose derivative was used as the chiral separator. After 50 cycles of the operation (in 9h), 0.1g of (-)-enantiomer (85% in purity) was recovered from the solid phase by back-extraction with ethanol, whereas 1.1g of (+)-isomer (75% in purity) was collected from the liquid phase (ethanol).

KW - Counter-current extraction

KW - Enantiomer separation

KW - Extraction methods

KW - Instrumentation

KW - True moving beds

KW - Tröger's base

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U2 - 10.1016/j.chroma.2003.08.013

DO - 10.1016/j.chroma.2003.08.013

M3 - Article

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AN - SCOPUS:0141639649

SN - 0021-9673

VL - 1017

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EP - 69

JO - Journal of Chromatography A

JF - Journal of Chromatography A

IS - 1-2

ER -

Improved apparatus for solid-liquid multi-stage counter-current extraction

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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