Improved apparatus for solid-liquid multi-stage counter-current extraction

Kayoko Tahara, Yoshihiro Abe, Setsuro Sugata, Hideyuki Nishizawa, Takashi Nishikawa, Hiroshi Suzuki, Makoto Takeuchi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An improved apparatus for solid-liquid multi-stage counter-current extraction (SLME) was developed. The apparatus has a set of 24 extraction vessels. Each extraction vessel unit is composed of a piston-cylinder in which the solid phase is placed, and a cup-cylinder in which the liquid phase is set. Of the 24 extraction vessels, 20 were used for the separation stage, and the other 4 were used for the back-extraction stage. (±)-Troger's base was selected as a racemic model compound for the continuous enantioseparation by the apparatus, and a cellulose derivative was used as the chiral separator. After 50 cycles of the operation (in 9h), 0.1g of (-)-enantiomer (85% in purity) was recovered from the solid phase by back-extraction with ethanol, whereas 1.1g of (+)-isomer (75% in purity) was collected from the liquid phase (ethanol).

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalJournal of Chromatography A
Volume1017
Issue number1-2
DOIs
Publication statusPublished - 2003 Oct 31

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Ethanol
Solid Phase Extraction
Liquids
Cellulose
Cellulose derivatives
Enantiomers
Separators
Isomers
Pistons

Keywords

  • Counter-current extraction
  • Enantiomer separation
  • Extraction methods
  • Instrumentation
  • Tröger's base
  • True moving beds

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Tahara, K., Abe, Y., Sugata, S., Nishizawa, H., Nishikawa, T., Suzuki, H., & Takeuchi, M. (2003). Improved apparatus for solid-liquid multi-stage counter-current extraction. Journal of Chromatography A, 1017(1-2), 63-69. https://doi.org/10.1016/j.chroma.2003.08.013

Improved apparatus for solid-liquid multi-stage counter-current extraction. / Tahara, Kayoko; Abe, Yoshihiro; Sugata, Setsuro; Nishizawa, Hideyuki; Nishikawa, Takashi; Suzuki, Hiroshi; Takeuchi, Makoto.

In: Journal of Chromatography A, Vol. 1017, No. 1-2, 31.10.2003, p. 63-69.

Research output: Contribution to journalArticle

Tahara, K, Abe, Y, Sugata, S, Nishizawa, H, Nishikawa, T, Suzuki, H & Takeuchi, M 2003, 'Improved apparatus for solid-liquid multi-stage counter-current extraction', Journal of Chromatography A, vol. 1017, no. 1-2, pp. 63-69. https://doi.org/10.1016/j.chroma.2003.08.013
Tahara K, Abe Y, Sugata S, Nishizawa H, Nishikawa T, Suzuki H et al. Improved apparatus for solid-liquid multi-stage counter-current extraction. Journal of Chromatography A. 2003 Oct 31;1017(1-2):63-69. https://doi.org/10.1016/j.chroma.2003.08.013
Tahara, Kayoko ; Abe, Yoshihiro ; Sugata, Setsuro ; Nishizawa, Hideyuki ; Nishikawa, Takashi ; Suzuki, Hiroshi ; Takeuchi, Makoto. / Improved apparatus for solid-liquid multi-stage counter-current extraction. In: Journal of Chromatography A. 2003 ; Vol. 1017, No. 1-2. pp. 63-69.
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