Improved total synthesis of incednam

Akira Takada, Kanjiro Uda, Takashi Ohtani, Shinya Tsukamoto, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An alternative and improved total synthesis of incednam, the aglycon of the 24-membered macrolactam glycoside antibiotic incednine, was accomplished. The synthesis was realized via construction of the 24-membered macrocycle using intramolecular ring-closing olefin metathesis reaction as a key step.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalJournal of Antibiotics
Volume66
Issue number3
DOIs
Publication statusPublished - 2013 Mar

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Alkenes
Glycosides
Anti-Bacterial Agents
incednam
incednine

Keywords

  • incednam
  • incednine
  • olefin metathesis
  • total synthesis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Improved total synthesis of incednam. / Takada, Akira; Uda, Kanjiro; Ohtani, Takashi; Tsukamoto, Shinya; Takahashi, Daisuke; Toshima, Kazunobu.

In: Journal of Antibiotics, Vol. 66, No. 3, 03.2013, p. 155-159.

Research output: Contribution to journalArticle

Takada, A, Uda, K, Ohtani, T, Tsukamoto, S, Takahashi, D & Toshima, K 2013, 'Improved total synthesis of incednam', Journal of Antibiotics, vol. 66, no. 3, pp. 155-159. https://doi.org/10.1038/ja.2013.4
Takada, Akira ; Uda, Kanjiro ; Ohtani, Takashi ; Tsukamoto, Shinya ; Takahashi, Daisuke ; Toshima, Kazunobu. / Improved total synthesis of incednam. In: Journal of Antibiotics. 2013 ; Vol. 66, No. 3. pp. 155-159.
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