Improved total synthesis of incednam

Akira Takada, Kanjiro Uda, Takashi Ohtani, Shinya Tsukamoto, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An alternative and improved total synthesis of incednam, the aglycon of the 24-membered macrolactam glycoside antibiotic incednine, was accomplished. The synthesis was realized via construction of the 24-membered macrocycle using intramolecular ring-closing olefin metathesis reaction as a key step.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalJournal of Antibiotics
Volume66
Issue number3
DOIs
Publication statusPublished - 2013 Mar 1

Keywords

  • incednam
  • incednine
  • olefin metathesis
  • total synthesis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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