In a non-diabetic Japanese population, the combination of macroalbuminuria and increased urine beta 2-microglobulin predicts a decline of renal function: The Takahata study

Ami Ikeda, Tsuneo Konta, Satoshi Takasaki, Zhimei Hao, Kazuko Suzuki, Hitoshi Sato, Yoko Shibata, Yasuchika Takeishi, Takeo Kato, Sumio Kawata, Isao Kubota

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background. Glomerular and tubular damage are important factors in the development of renal insufficiency. However, the interaction of these factors is largely unknown in the non-diabetic Japanese population. To clarify the relationship between renal insufficiency and both glomerular and tubular damage, we conducted a community-based study using albuminuria and urine beta 2-microglobulin as markers of glomerular and tubular damages, respecti- vely. Methods. Subjects of this study were 2816 non-diabetic individuals >40 years old in Takahata, Japan. The urine albumin-creatinine ratio (UACR) and urine beta 2-microglobulin-creatinine ratio (UBCR) were assessed from single spot urine. The glomerular filtration rate (eGFR) was estimated using the abbreviated MDRD equation with a Japanese coefficient. Results. The prevalence of albuminuria (UACR >20 mg/ g in men and >30 mg/g in women), increased UBCR (>300 μg/g) and renal insufficiency (eGFR <60 mL/ min/1.73 m2) were 21.0%, 12.5% and 21.7%, respectively, and there was only a small overlap between the three. The mean eGFR was significantly lower in subjects with macroalbuminuria (UACR >200 mg/g in men and >300 mg/g in women) and increased UBCR. No urinary abnormalities were observed in 71.7% of the 611 subjects with renal insufficiency, and were more common in young, women and the non-hypertensive population. The 1-year decline of eGFR was greatest in subjects with an overlap of macroalbuminuria and increased UBCR. Conclusions. This study indicated that only a small part of renal insufficiency accompanied increased urine albumin or beta 2-microglobulin in the non-diabetic Japanese population. The combination of macroalbuminuria and increased urine beta 2-microglobulin might predict faster renal deterioration.

Original languageEnglish
Pages (from-to)841-847
Number of pages7
JournalNephrology Dialysis Transplantation
Volume24
Issue number3
DOIs
Publication statusPublished - 2009 Mar 1

Keywords

  • Albuminuria
  • Beta 2-microglobulin
  • General population
  • Renal insufficiency

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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