In-bore setup and software for 3T MRI-guided transperineal prostate biopsy

Junichi Tokuda, Kemal Tuncali, Iulian Iordachita, Sang Eun Song, Andriy Fedorov, Sota Oguro, Andras Lasso, Fiona M. Fennessy, Clare M. Tempany, Nobuhiko Hata

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

MRI-guided prostate biopsy in conventional closed-bore scanners requires transferring the patient outside the bore during needle insertion due to the constrained in-bore space, causing a safety hazard and limiting image feedback. To address this issue, we present our custom-made in-bore setup and software to support MRI-guided transperineal prostate biopsy in a wide-bore 3 T MRI scanner. The setup consists of a specially designed tabletop and a needle-guiding template with a Z-frame that gives a physician access to the perineum of the patient at the imaging position and allows the physician to perform MRI-guided transperineal biopsy without moving the patient out of the scanner. The software and Z-frame allow registration of the template, target planning and biopsy guidance. Initially, we performed phantom experiments to assess the accuracy of template registration and needle placement in a controlled environment. Subsequently, we embarked on our clinical trial (N = 10). The phantom experiments showed that the translational errors of the template registration along the right-left (RP) and anterior-posterior (AP) axes were 1.1 ± 0.8 and 1.4 ± 1.1 mm, respectively, while the rotational errors around the RL, AP and superior-inferior axes were (0.8 ± 1.0)°, (1.7 ± 1.6)° and (0.0 ± 0.0)°, respectively. The 2D root-mean-square (RMS) needle-placement error was 3 mm. The clinical biopsy procedures were safely carried out in all ten clinical cases with a needle-placement error of 5.4 mm (2D RMS). In conclusion, transperineal prostate biopsy in a wide-bore 3T scanner is feasible using our custom-made tabletop setup and software, which supports manual needle placement without moving the patient out of the magnet.

Original languageEnglish
Pages (from-to)5823-5840
Number of pages18
JournalPhysics in Medicine and Biology
Volume57
Issue number18
DOIs
Publication statusPublished - 2012 Sep 21

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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    Tokuda, J., Tuncali, K., Iordachita, I., Song, S. E., Fedorov, A., Oguro, S., Lasso, A., Fennessy, F. M., Tempany, C. M., & Hata, N. (2012). In-bore setup and software for 3T MRI-guided transperineal prostate biopsy. Physics in Medicine and Biology, 57(18), 5823-5840. https://doi.org/10.1088/0031-9155/57/18/5823