In-bore setup and software for 3T MRI-guided transperineal prostate biopsy

Junichi Tokuda, Kemal Tuncali, Iulian Iordachita, Sang Eun Song, Andriy Fedorov, Sota Oguro, Andras Lasso, Fiona M. Fennessy, Clare M. Tempany, Nobuhiko Hata

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

MRI-guided prostate biopsy in conventional closed-bore scanners requires transferring the patient outside the bore during needle insertion due to the constrained in-bore space, causing a safety hazard and limiting image feedback. To address this issue, we present our custom-made in-bore setup and software to support MRI-guided transperineal prostate biopsy in a wide-bore 3 T MRI scanner. The setup consists of a specially designed tabletop and a needle-guiding template with a Z-frame that gives a physician access to the perineum of the patient at the imaging position and allows the physician to perform MRI-guided transperineal biopsy without moving the patient out of the scanner. The software and Z-frame allow registration of the template, target planning and biopsy guidance. Initially, we performed phantom experiments to assess the accuracy of template registration and needle placement in a controlled environment. Subsequently, we embarked on our clinical trial (N = 10). The phantom experiments showed that the translational errors of the template registration along the right-left (RP) and anterior-posterior (AP) axes were 1.1 ± 0.8 and 1.4 ± 1.1 mm, respectively, while the rotational errors around the RL, AP and superior-inferior axes were (0.8 ± 1.0)°, (1.7 ± 1.6)° and (0.0 ± 0.0)°, respectively. The 2D root-mean-square (RMS) needle-placement error was 3 mm. The clinical biopsy procedures were safely carried out in all ten clinical cases with a needle-placement error of 5.4 mm (2D RMS). In conclusion, transperineal prostate biopsy in a wide-bore 3T scanner is feasible using our custom-made tabletop setup and software, which supports manual needle placement without moving the patient out of the magnet.

Original languageEnglish
Pages (from-to)5823-5840
Number of pages18
JournalPhysics in Medicine and Biology
Volume57
Issue number18
DOIs
Publication statusPublished - 2012 Sep 21
Externally publishedYes

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Needles
Prostate
Software
Biopsy
Moving and Lifting Patients
Physicians
Controlled Environment
Perineum
Magnets
Clinical Trials
Safety

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Tokuda, J., Tuncali, K., Iordachita, I., Song, S. E., Fedorov, A., Oguro, S., ... Hata, N. (2012). In-bore setup and software for 3T MRI-guided transperineal prostate biopsy. Physics in Medicine and Biology, 57(18), 5823-5840. https://doi.org/10.1088/0031-9155/57/18/5823

In-bore setup and software for 3T MRI-guided transperineal prostate biopsy. / Tokuda, Junichi; Tuncali, Kemal; Iordachita, Iulian; Song, Sang Eun; Fedorov, Andriy; Oguro, Sota; Lasso, Andras; Fennessy, Fiona M.; Tempany, Clare M.; Hata, Nobuhiko.

In: Physics in Medicine and Biology, Vol. 57, No. 18, 21.09.2012, p. 5823-5840.

Research output: Contribution to journalArticle

Tokuda, J, Tuncali, K, Iordachita, I, Song, SE, Fedorov, A, Oguro, S, Lasso, A, Fennessy, FM, Tempany, CM & Hata, N 2012, 'In-bore setup and software for 3T MRI-guided transperineal prostate biopsy', Physics in Medicine and Biology, vol. 57, no. 18, pp. 5823-5840. https://doi.org/10.1088/0031-9155/57/18/5823
Tokuda J, Tuncali K, Iordachita I, Song SE, Fedorov A, Oguro S et al. In-bore setup and software for 3T MRI-guided transperineal prostate biopsy. Physics in Medicine and Biology. 2012 Sep 21;57(18):5823-5840. https://doi.org/10.1088/0031-9155/57/18/5823
Tokuda, Junichi ; Tuncali, Kemal ; Iordachita, Iulian ; Song, Sang Eun ; Fedorov, Andriy ; Oguro, Sota ; Lasso, Andras ; Fennessy, Fiona M. ; Tempany, Clare M. ; Hata, Nobuhiko. / In-bore setup and software for 3T MRI-guided transperineal prostate biopsy. In: Physics in Medicine and Biology. 2012 ; Vol. 57, No. 18. pp. 5823-5840.
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