In Situ Generation of Ruthenium Carbonyl Phosphine Complexes as a Versatile Method for the Development of Enantioselective C−O Bond Arylation

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Abstract

We report here a method for in situ generation of various ruthenium carbonyl phosphine catalysts for arylation via cleavage of inert aromatic carbon–oxygen bonds. The use of catalyst systems consisting of [RuCl2(CO)(p-cymene)], CsF, styrene, and phosphines enabled facile screening of phosphine ligands. Asymmetric C–O arylation was also achieved for atropo-enantioselective biaryl synthesis using a chiral monodentate phosphine ligand.

Original languageEnglish
Pages (from-to)1737-1741
Number of pages5
JournalChemistry - A European Journal
Volume26
Issue number8
DOIs
Publication statusPublished - 2020 Feb 6

Keywords

  • asymmetric synthesis
  • cleavage reactions
  • homogeneous catalysis
  • ruthenium
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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