In situ synthesis of polysaccharide nanoparticles via polyion complex of carboxymethyl cellulose and chitosan

Sachiko Kaihara, Yoichi Suzuki, Keiji Fujimoto

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Biocompatible polymer-magnetite hybrid nanoparticles were prepared by means of in situ synthesis of magnetite within polysaccharide hydrogel nanoparticles. Hydrogel nanoparticles were first fabricated by blending high-molecular-weight carboxymethyl cellulose as an anionic polymer, and low-molecular-weight chitosan as a cationic polymer to form polyion complexes (CC particles). These polyion complexes were then chemically crosslinked using genipin, a bio-based cross-linker, to form stable nanoparticles having a semi-IPN structure (CCG particles). Magnetite was lastly synthesized within CCG particles by the coprecipitation method to obtain polymer-magnetite hybrid nanoparticles (CCGM particles). The formations of CC, CCG and CCGM particles were mainly observed by transmittance, absorbance of genipin and TEM, respectively, and their hydrodynamic diameters and zeta-potentials were analyzed. It was confirmed that the hydrodynamic diameters and the zeta-potentials of these particles were significantly influenced by pH of the suspension, which was attributed to the charges of polymers. The diameters of CCGM particles were smaller than 200. nm at any pH conditions, suggesting the possibility to apply them as drug delivery carriers. CCGM particles exhibited the responsiveness to a magnetic field in addition to their high dispersion stability, indicating their potential to be utilized as a biomaterial for hyperthermia.

Original languageEnglish
Pages (from-to)343-348
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
Volume85
Issue number2
DOIs
Publication statusPublished - 2011 Jul 1

Fingerprint

Carboxymethylcellulose Sodium
polysaccharides
Ferrosoferric Oxide
Polysaccharides
cellulose
Chitosan
Nanoparticles
Magnetite
Cellulose
Polymers
Magnetite Nanoparticles
nanoparticles
synthesis
magnetite
Hydrogel
Zeta potential
Hydrodynamics
Hydrogels
polymers
Molecular Weight

Keywords

  • In situ synthesis
  • Magnetite
  • Polyion complex
  • Polysaccharide
  • Semi-IPN network

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

Cite this

In situ synthesis of polysaccharide nanoparticles via polyion complex of carboxymethyl cellulose and chitosan. / Kaihara, Sachiko; Suzuki, Yoichi; Fujimoto, Keiji.

In: Colloids and Surfaces B: Biointerfaces, Vol. 85, No. 2, 01.07.2011, p. 343-348.

Research output: Contribution to journalArticle

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