In vitro activity of tebipenem, a new oral carbapenem antibiotic, against β-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae

Kozue Kishii, Naoko Chiba, Miyuki Morozumi, Akiko Ono, Takashi Ida, Kimiko Ubukata

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In vitro activity of tebipenem, a new oral carbapenem antibiotic, against clinical Haemophilus influenzae isolates was compared with those of 8 reference agents. Isolates were classified into 6 resistance classes after PCR identification of β-lactamase genes and ftsI gene mutations. For all isolates, the minimal concentration at which 90% of isolates were inhibited was lower for tebipenem than for the reference oral antibiotics, except for cefditoren. Tebipenem also showed excellent bactericidal activity against β-lactamase-nonproducing, ampicillin-resistant isolates.

Original languageEnglish
Pages (from-to)3970-3973
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number9
DOIs
Publication statusPublished - 2010 Sep
Externally publishedYes

Fingerprint

Carbapenems
Haemophilus influenzae
Ampicillin
Genes
Anti-Bacterial Agents
Polymerase Chain Reaction
Mutation
tebipenem
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

In vitro activity of tebipenem, a new oral carbapenem antibiotic, against β-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. / Kishii, Kozue; Chiba, Naoko; Morozumi, Miyuki; Ono, Akiko; Ida, Takashi; Ubukata, Kimiko.

In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 9, 09.2010, p. 3970-3973.

Research output: Contribution to journalArticle

Kishii, Kozue ; Chiba, Naoko ; Morozumi, Miyuki ; Ono, Akiko ; Ida, Takashi ; Ubukata, Kimiko. / In vitro activity of tebipenem, a new oral carbapenem antibiotic, against β-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae. In: Antimicrobial Agents and Chemotherapy. 2010 ; Vol. 54, No. 9. pp. 3970-3973.
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