In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment

Takashi Ota, Masamitsu Nakayama, Yoshihiko Kanno, Tetsuya Suzuki, Norihisa Miki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this report, we experimentally investigated the blood hemofiltration capacity of a nanoporous dialysis membrane (poly(ether sulfone), PES) whose surface was modified with fluorine-doped diamond-like carbon(f-DLC). Surface modification of the nanoporous membrane without clogging the nanopores is challenging. In vitro experiments revealed that the modified membrane successfully exhibited water permeability of one-tenth of the untreated. In vivo experiments with ultra-small hemofiltration devices composed of f-DLC PES membranes using SD rats were also conducted for the first time. The results proved that the f-DLC coated PES membrane can be used for hemofiltration, which will extend the lifetime of microfluidics-based implantable artificial kidney.

Original languageEnglish
Title of host publication2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages412-414
Number of pages3
Volume2018-January
ISBN (Electronic)9781538647820
DOIs
Publication statusPublished - 2018 Apr 24
Event31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018 - Belfast, United Kingdom
Duration: 2018 Jan 212018 Jan 25

Other

Other31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018
CountryUnited Kingdom
CityBelfast
Period18/1/2118/1/25

Fingerprint

Diamond
Fluorine
fluorine
Diamonds
Carbon
diamonds
membranes
Membranes
carbon
Dialysis membranes
Sulfones
Nanopores
plugging
dialysis
Microfluidics
sulfones
Ether
Surface treatment
Rats
kidneys

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

Ota, T., Nakayama, M., Kanno, Y., Suzuki, T., & Miki, N. (2018). In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018 (Vol. 2018-January, pp. 412-414). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2018.8346575

In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment. / Ota, Takashi; Nakayama, Masamitsu; Kanno, Yoshihiko; Suzuki, Tetsuya; Miki, Norihisa.

2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Vol. 2018-January Institute of Electrical and Electronics Engineers Inc., 2018. p. 412-414.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ota, T, Nakayama, M, Kanno, Y, Suzuki, T & Miki, N 2018, In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment. in 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. vol. 2018-January, Institute of Electrical and Electronics Engineers Inc., pp. 412-414, 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018, Belfast, United Kingdom, 18/1/21. https://doi.org/10.1109/MEMSYS.2018.8346575
Ota T, Nakayama M, Kanno Y, Suzuki T, Miki N. In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Vol. 2018-January. Institute of Electrical and Electronics Engineers Inc. 2018. p. 412-414 https://doi.org/10.1109/MEMSYS.2018.8346575
Ota, Takashi ; Nakayama, Masamitsu ; Kanno, Yoshihiko ; Suzuki, Tetsuya ; Miki, Norihisa. / In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment. 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Vol. 2018-January Institute of Electrical and Electronics Engineers Inc., 2018. pp. 412-414
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