In Vitro Artery Model with Circumferentially Aligned & Contractible Smooth Muscle by Unfixed Molding & Screwing Fabrication

Shun Itai, Hiroaki Onoe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper describes a fabrication method of an artery model with circumferentially aligned and contractible smooth muscle cells (SMCs) by unfixed molding and screwing processes. The fabricated aligned smooth muscle is well-deformable, enabling the flexible contraction in biological reaction. The axially aligned fiber-shaped smooth muscle tissue was formed by unfixed molding and screwed up to be aligned circumferentially. Also, the SMC layer was covered with a collagen layer with connectors to enable co-culture with endothelial cells (ECs) and perfusion culture. The alignment of SMCs was visibly confirmed, and the ability to reproduce the biochemical contraction was proved by an inflammatory reaction. We believe that our novel fabrication method would contribute to the development of functional smooth muscle models for biomedical researches.

Original languageEnglish
Title of host publication35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022
PublisherIEEE Computer Society
Pages275-278
Number of pages4
ISBN (Electronic)9781665409117
DOIs
Publication statusPublished - 2022
Event35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022 - Tokyo, Japan
Duration: 2022 Jan 92022 Jan 13

Publication series

NameIEEE Symposium on Mass Storage Systems and Technologies
Volume2022-January
ISSN (Print)2160-1968

Conference

Conference35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022
Country/TerritoryJapan
CityTokyo
Period22/1/922/1/13

Keywords

  • Alignment
  • In vitro blood vessel
  • Molding
  • Smooth Muscle Cells
  • Tissue engineering
  • collagen
  • histamine

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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