In vitro combination effect of glycopeptides and β-lactams against methicillin-resistant Staphylococcus aureus

Yoshitake Sato, Mitsuru Sando, Satoshi Iwata, Hironobu Akita, Keisuke Sunakawa

Research output: Contribution to journalArticle

Abstract

We investigated the combination effect of teicoplanin (TEIC) or vancomycin (VCM) and 6 β-lactams in vitro using 49 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from neonates who were admitted to the newborn intensive care unit. We combined TEIC with imipenem (IPM), meropenem (MEPM), panipenem (PAPM), cefpirome (CPR), flomoxef (FMOX), or sulbactam (SBT)/ampicillin (ABPC). Synergistic effects were noted in 16 to 48 strains. In particular, the combinations of TEIC and IPM, MEPM, PAPM, or FMOX showed synergistic effects in many strains. Furthermore, 3 strains did not respond to the combination of TEIC and CPR; however, none of the strains exhibited antagonism. Combination with VCM and the above β-lactams produced synergistic effects in 1 to 32 strains. No changes were seen in 1 to 17 strains, and 2 to 6 strains exhibited antagonism. These results suggest that, when combined with the β-lactams tested, TEIC exhibits more potent synergistic effects than VCM.

Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalJapanese Journal of Chemotherapy
Volume54
Issue number2
Publication statusPublished - 2006 Feb
Externally publishedYes

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Keywords

  • β-lactam
  • Combination effect
  • MRSA
  • Teicoplanin
  • Vancomycin

ASJC Scopus subject areas

  • Pharmacology

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