In vitro gene delivery by pDNA/chitosan complexes coated with anionic PEG derivatives that have a sugar side chain

Mayu Hashimoto, Yoshiyuki Koyama, Toshinori Sato

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We developed pDNA/chitosan complexes coated with sugar-modified PEG-A/Cs, which are poly(ethylene glycol) derivatives with a side chain of carboxylic acid and sugar. The cationic pDNA/chitosan complexes were coated with anionic sugar-modified PEG-Cs, and anionic ternary complexes were formed. Coating the pDNA/chitosan complexes with maltose-or lactose-modified PEG-A/C (Mal-PEG-A/C or Lac-PEG-A/C, respectively) greatly promoted their stability in water and transfection efficiency in vitro.

Original languageEnglish
Pages (from-to)266-267
Number of pages2
JournalChemistry Letters
Volume37
Issue number3
DOIs
Publication statusPublished - 2008 Mar 5

ASJC Scopus subject areas

  • Chemistry(all)

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