In vitro leishmanicidal constituents of Millettia pendula

Marii Takahashi; Hiroyuki Fuchino; Setsuko Sekita; Motoyoshi Satake; Fumiyuki Kiuchi

doi:10.1248/cpb.54.915

In vitro leishmanicidal constituents of Millettia pendula

Marii Takahashi, Hiroyuki Fuchino, Setsuko Sekita, Motoyoshi Satake, Fumiyuki Kiuchi

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The in vitro leishmanicidal constituents of Millettia pendula were examined. Two new compounds, 1 (millettilone A) and 2 (millettilone B), were isolated from the methanol extract of M. pendula, together with six known compounds: 3R-claussequinone (3), pendulone (4), secundiflorol I (5), 3,8-dihydroxy-9-methoxypterocarpan (6), 3,10-dihydroxy-7,9-dimethoxypterocarpan (7), and formononetin (8). Among these, pendulone showed the most potent leishmanicidal activity. Compound 2 was found to be a purple pigment in this heartwood. Their chemical structures were elucidated using spectral methods.

Original language	English
Pages (from-to)	915-917
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	54
Issue number	6
DOIs	https://doi.org/10.1248/cpb.54.915
Publication status	Published - 2006 Jun
Externally published	Yes

Keywords

Leguminosae
Leishmaniasis
Millettia pendula
Myanmar
Pigment

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.54.915

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abstract = "The in vitro leishmanicidal constituents of Millettia pendula were examined. Two new compounds, 1 (millettilone A) and 2 (millettilone B), were isolated from the methanol extract of M. pendula, together with six known compounds: 3R-claussequinone (3), pendulone (4), secundiflorol I (5), 3,8-dihydroxy-9-methoxypterocarpan (6), 3,10-dihydroxy-7,9-dimethoxypterocarpan (7), and formononetin (8). Among these, pendulone showed the most potent leishmanicidal activity. Compound 2 was found to be a purple pigment in this heartwood. Their chemical structures were elucidated using spectral methods.",

keywords = "Leguminosae, Leishmaniasis, Millettia pendula, Myanmar, Pigment",

author = "Marii Takahashi and Hiroyuki Fuchino and Setsuko Sekita and Motoyoshi Satake and Fumiyuki Kiuchi",

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T1 - In vitro leishmanicidal constituents of Millettia pendula

AU - Takahashi, Marii

AU - Fuchino, Hiroyuki

AU - Sekita, Setsuko

AU - Satake, Motoyoshi

AU - Kiuchi, Fumiyuki

PY - 2006/6

Y1 - 2006/6

N2 - The in vitro leishmanicidal constituents of Millettia pendula were examined. Two new compounds, 1 (millettilone A) and 2 (millettilone B), were isolated from the methanol extract of M. pendula, together with six known compounds: 3R-claussequinone (3), pendulone (4), secundiflorol I (5), 3,8-dihydroxy-9-methoxypterocarpan (6), 3,10-dihydroxy-7,9-dimethoxypterocarpan (7), and formononetin (8). Among these, pendulone showed the most potent leishmanicidal activity. Compound 2 was found to be a purple pigment in this heartwood. Their chemical structures were elucidated using spectral methods.

AB - The in vitro leishmanicidal constituents of Millettia pendula were examined. Two new compounds, 1 (millettilone A) and 2 (millettilone B), were isolated from the methanol extract of M. pendula, together with six known compounds: 3R-claussequinone (3), pendulone (4), secundiflorol I (5), 3,8-dihydroxy-9-methoxypterocarpan (6), 3,10-dihydroxy-7,9-dimethoxypterocarpan (7), and formononetin (8). Among these, pendulone showed the most potent leishmanicidal activity. Compound 2 was found to be a purple pigment in this heartwood. Their chemical structures were elucidated using spectral methods.

KW - Leguminosae

KW - Leishmaniasis

KW - Millettia pendula

KW - Myanmar

KW - Pigment

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In vitro leishmanicidal constituents of Millettia pendula

Abstract

Keywords

ASJC Scopus subject areas

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