In vitro leishmanicidal constituents of Millettia pendula

Marii Takahashi, Hiroyuki Fuchino, Setsuko Sekita, Motoyoshi Satake, Fumiyuki Kiuchi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The in vitro leishmanicidal constituents of Millettia pendula were examined. Two new compounds, 1 (millettilone A) and 2 (millettilone B), were isolated from the methanol extract of M. pendula, together with six known compounds: 3R-claussequinone (3), pendulone (4), secundiflorol I (5), 3,8-dihydroxy-9-methoxypterocarpan (6), 3,10-dihydroxy-7,9-dimethoxypterocarpan (7), and formononetin (8). Among these, pendulone showed the most potent leishmanicidal activity. Compound 2 was found to be a purple pigment in this heartwood. Their chemical structures were elucidated using spectral methods.

Original languageEnglish
Pages (from-to)915-917
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume54
Issue number6
DOIs
Publication statusPublished - 2006 Jun 1
Externally publishedYes

Keywords

  • Leguminosae
  • Leishmaniasis
  • Millettia pendula
  • Myanmar
  • Pigment

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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