Abstract
This study was designed to clarify the in vitro solubility and the in vivo basic toxicity of indium phosphide (InP). InP powder was clearly soluble in synthetic gastric fluid and quite insoluble in saline or synthetic lung fluid. Male ICR mice (SPF grade) were given InP at the doses of 0, 1,000, 3,000, and 5,000 mg/kg, intraperitoneally (i. p.) or orally (p. o.). During a 2-week observation, no mice died. In i. p. treated mice, the serum indium concentration showed a dose-dependent increase, and indium mainly accumulated in the lungs and liver. Dose-dependent increases in lung and spleen weight were observed. Black granules of InP were deposited in the lymph nodes, spleen, lungs, and liver. Extramedullary granulopoiesis was observed. And eosinophilic exudates and mononuclear cells were seen in the pulmonary alveoli. Considering these findings, InP particles were presumably transferred to the spleen, liver, and lungs by way of lymphokinetics, causing reticuloendothelial responses. Hematological examination showed increased proportions of stab cells and monocytes in 5000 mg/kg i. p. dosed mice. The p. o. administered mice showed no clear relationship between the dose and biological effects.
| Original language | English |
|---|---|
| Pages (from-to) | 6-12 |
| Number of pages | 7 |
| Journal | Journal of Occupational Health |
| Volume | 38 |
| Issue number | 1 |
| Publication status | Published - 1996 Jan |
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Keywords
- Indium phosphide
- Lethal dose
- Mouse
- Semiconductor
- Solubility
- Toxicity
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Toxicology
Cite this
In vitro solubility and in vivo toxicity of indium phosphide. / Kabe, Isamu; Omae, Kazuyuki; Nakashima, Hiroshi; Nomiyama, Tetsuo; Uemura, Takamoto; Hosoda, Kanae; Ishizuka, Chizuru; Yamazaki, Kazuto; Sakurai, Haruhiko.
In: Journal of Occupational Health, Vol. 38, No. 1, 01.1996, p. 6-12.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro solubility and in vivo toxicity of indium phosphide
AU - Kabe, Isamu
AU - Omae, Kazuyuki
AU - Nakashima, Hiroshi
AU - Nomiyama, Tetsuo
AU - Uemura, Takamoto
AU - Hosoda, Kanae
AU - Ishizuka, Chizuru
AU - Yamazaki, Kazuto
AU - Sakurai, Haruhiko
PY - 1996/1
Y1 - 1996/1
N2 - This study was designed to clarify the in vitro solubility and the in vivo basic toxicity of indium phosphide (InP). InP powder was clearly soluble in synthetic gastric fluid and quite insoluble in saline or synthetic lung fluid. Male ICR mice (SPF grade) were given InP at the doses of 0, 1,000, 3,000, and 5,000 mg/kg, intraperitoneally (i. p.) or orally (p. o.). During a 2-week observation, no mice died. In i. p. treated mice, the serum indium concentration showed a dose-dependent increase, and indium mainly accumulated in the lungs and liver. Dose-dependent increases in lung and spleen weight were observed. Black granules of InP were deposited in the lymph nodes, spleen, lungs, and liver. Extramedullary granulopoiesis was observed. And eosinophilic exudates and mononuclear cells were seen in the pulmonary alveoli. Considering these findings, InP particles were presumably transferred to the spleen, liver, and lungs by way of lymphokinetics, causing reticuloendothelial responses. Hematological examination showed increased proportions of stab cells and monocytes in 5000 mg/kg i. p. dosed mice. The p. o. administered mice showed no clear relationship between the dose and biological effects.
AB - This study was designed to clarify the in vitro solubility and the in vivo basic toxicity of indium phosphide (InP). InP powder was clearly soluble in synthetic gastric fluid and quite insoluble in saline or synthetic lung fluid. Male ICR mice (SPF grade) were given InP at the doses of 0, 1,000, 3,000, and 5,000 mg/kg, intraperitoneally (i. p.) or orally (p. o.). During a 2-week observation, no mice died. In i. p. treated mice, the serum indium concentration showed a dose-dependent increase, and indium mainly accumulated in the lungs and liver. Dose-dependent increases in lung and spleen weight were observed. Black granules of InP were deposited in the lymph nodes, spleen, lungs, and liver. Extramedullary granulopoiesis was observed. And eosinophilic exudates and mononuclear cells were seen in the pulmonary alveoli. Considering these findings, InP particles were presumably transferred to the spleen, liver, and lungs by way of lymphokinetics, causing reticuloendothelial responses. Hematological examination showed increased proportions of stab cells and monocytes in 5000 mg/kg i. p. dosed mice. The p. o. administered mice showed no clear relationship between the dose and biological effects.
KW - Indium phosphide
KW - Lethal dose
KW - Mouse
KW - Semiconductor
KW - Solubility
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=0008338460&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0008338460&partnerID=8YFLogxK
M3 - Article
VL - 38
SP - 6
EP - 12
JO - Journal of Occupational Health
JF - Journal of Occupational Health
SN - 1341-9145
IS - 1
ER -