In vitro translation-based computations

Yasubumi Sakakibara; Takahiro Hohsaka

doi:10.1007/978-3-540-24628-2_19

In vitro translation-based computations

Yasubumi Sakakibara, Takahiro Hohsaka

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The translation system in a cell is a powerful molecular machine conducted by ribosomes, tRNAs, and several translation factors to synthesize proteins. The translation process is very accurate according to the genetic code and directed from 5′-end to 3′-end on messenger RNA. We employ the translation mechanism combined with four-base codon techniques to develop a molecular machine which computes finite automata (finite-state machine). We report some experimental results where we have succeeded to implement a finite automaton on an E. coli in vitro translation system with four-base codons.

Original language	English
Pages (from-to)	197-202
Number of pages	6
Journal	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	2943
DOIs	https://doi.org/10.1007/978-3-540-24628-2_19
Publication status	Published - 2004

ASJC Scopus subject areas

Theoretical Computer Science
Computer Science(all)

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10.1007/978-3-540-24628-2_19

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AB - The translation system in a cell is a powerful molecular machine conducted by ribosomes, tRNAs, and several translation factors to synthesize proteins. The translation process is very accurate according to the genetic code and directed from 5′-end to 3′-end on messenger RNA. We employ the translation mechanism combined with four-base codon techniques to develop a molecular machine which computes finite automata (finite-state machine). We report some experimental results where we have succeeded to implement a finite automaton on an E. coli in vitro translation system with four-base codons.

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In vitro translation-based computations

Abstract

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