In Vivo 3D Localized 13C Spectroscopy Using Modified INEPT and DEPT

H. Watanabe, Y. Ishihara, K. Okamoto, Koichi Oshio, T. Kanamatsu, Y. Tsukada

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Abstract

The 3D localized 13C spectroscopy methods LINEPT and LODEPT, which are modifications of INEPT and DEPT, are proposed. As long as a 13C inversion pulse (180-degree pulse) is applied at 1/(4J) before the proton echo time in LINEPT and a 13C excitation pulse (90-degree pulse) is applied at 1/(2J) before the proton echo time in LODEPT, the proton echo time can be set to any value longer than 1J(2J) in LINEPT and longer than 1/J in LODEPT. As a result, the proton and the 13C pulses can be applied separately and these proton pulses can be made slice-selective pulses. These localization features of LINEPT and LODEPT were evaluated using a phantom consisting of a cylinder filled with ethanol placed inside another cylinder filled with oil, and localized ethanol spectra could be obtained. In vivo 3D localized 13C spectra from the brain of a monkey could be obtained using decoupled LINEPT, and glutamate C-4 appeared directly after the administration of glucose C-1, followed by the appearance of glutamate C-2, C-3 and glutamine C-2, C-3, C-4.

Original languageEnglish
Pages (from-to)214-222
Number of pages9
JournalJournal of Magnetic Resonance
Volume134
Issue number2
Publication statusPublished - 1998 Oct
Externally publishedYes

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Keywords

  • C-MRS
  • DEPT
  • In vivo
  • INEPT
  • Localization

ASJC Scopus subject areas

  • Molecular Biology
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Watanabe, H., Ishihara, Y., Okamoto, K., Oshio, K., Kanamatsu, T., & Tsukada, Y. (1998). In Vivo 3D Localized 13C Spectroscopy Using Modified INEPT and DEPT. Journal of Magnetic Resonance, 134(2), 214-222.