In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone

M. Aizawa, M. Ito, K. Itatani, H. Suemasu, A. Nozue, I. Okada, M. Matsumoto, M. Ishikawa, H. Matsumoto, Y. Toyama

Research output: Contribution to journalConference article

9 Citations (Scopus)

Abstract

We fabricated the Hydroxyapatite(HAp)-PMMA hybrid material having mechanical properties similar to those of the cortical bone, using porous HAp ceramics with well-controlled pore sizes and bulk polymerization of MMA monomer without solvents. The histological results showed that the present hybrid material bonded directly to bone without intervening fibrous tissue between hybrid material and newly formed bone, and that a large amount of new bone was formed around the hybrid material. In addition, the results of in vitro evaluation also showed that the hybrid material in the present investigation has good biocompatibility.

Original languageEnglish
Pages (from-to)465-468
Number of pages4
JournalKey Engineering Materials
Volume218-220
Publication statusPublished - 2002 Jan 1
Event14th International Symposium on Ceramics in Medicine-Annual Meeting of the International Society for Ceramics in Medicine BIOCERAMICS'01 (ISCM) - Palm Springs, CA, United States
Duration: 2001 Nov 142001 Nov 17

Keywords

  • Biocompatibility
  • Ceramics/Polymer Hybrid Material
  • Hydroxyapatite
  • Mechanical Property
  • Osteoblast
  • PMMA
  • Tissue Reaction

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Aizawa, M., Ito, M., Itatani, K., Suemasu, H., Nozue, A., Okada, I., Matsumoto, M., Ishikawa, M., Matsumoto, H., & Toyama, Y. (2002). In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone. Key Engineering Materials, 218-220, 465-468.