Abstract
We fabricated the Hydroxyapatite(HAp)-PMMA hybrid material having mechanical properties similar to those of the cortical bone, using porous HAp ceramics with well-controlled pore sizes and bulk polymerization of MMA monomer without solvents. The histological results showed that the present hybrid material bonded directly to bone without intervening fibrous tissue between hybrid material and newly formed bone, and that a large amount of new bone was formed around the hybrid material. In addition, the results of in vitro evaluation also showed that the hybrid material in the present investigation has good biocompatibility.
| Original language | English |
|---|---|
| Pages (from-to) | 465-468 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 218-220 |
| Publication status | Published - 2002 |
| Externally published | Yes |
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Keywords
- Biocompatibility
- Ceramics/Polymer Hybrid Material
- Hydroxyapatite
- Mechanical Property
- Osteoblast
- PMMA
- Tissue Reaction
ASJC Scopus subject areas
- Ceramics and Composites
- Chemical Engineering (miscellaneous)
Cite this
In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone. / Aizawa, M.; Ito, M.; Itatani, K.; Suemasu, H.; Nozue, A.; Okada, I.; Matsumoto, Morio; Ishikawa, M.; Matsumoto, Hideo; Toyama, Y.
In: Key Engineering Materials, Vol. 218-220, 2002, p. 465-468.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone
AU - Aizawa, M.
AU - Ito, M.
AU - Itatani, K.
AU - Suemasu, H.
AU - Nozue, A.
AU - Okada, I.
AU - Matsumoto, Morio
AU - Ishikawa, M.
AU - Matsumoto, Hideo
AU - Toyama, Y.
PY - 2002
Y1 - 2002
N2 - We fabricated the Hydroxyapatite(HAp)-PMMA hybrid material having mechanical properties similar to those of the cortical bone, using porous HAp ceramics with well-controlled pore sizes and bulk polymerization of MMA monomer without solvents. The histological results showed that the present hybrid material bonded directly to bone without intervening fibrous tissue between hybrid material and newly formed bone, and that a large amount of new bone was formed around the hybrid material. In addition, the results of in vitro evaluation also showed that the hybrid material in the present investigation has good biocompatibility.
AB - We fabricated the Hydroxyapatite(HAp)-PMMA hybrid material having mechanical properties similar to those of the cortical bone, using porous HAp ceramics with well-controlled pore sizes and bulk polymerization of MMA monomer without solvents. The histological results showed that the present hybrid material bonded directly to bone without intervening fibrous tissue between hybrid material and newly formed bone, and that a large amount of new bone was formed around the hybrid material. In addition, the results of in vitro evaluation also showed that the hybrid material in the present investigation has good biocompatibility.
KW - Biocompatibility
KW - Ceramics/Polymer Hybrid Material
KW - Hydroxyapatite
KW - Mechanical Property
KW - Osteoblast
KW - PMMA
KW - Tissue Reaction
UR - http://www.scopus.com/inward/record.url?scp=0036169858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036169858&partnerID=8YFLogxK
M3 - Article
VL - 218-220
SP - 465
EP - 468
JO - Key Engineering Materials
JF - Key Engineering Materials
SN - 1013-9826
ER -