In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone

M. Aizawa; M. Ito; K. Itatani; H. Suemasu; A. Nozue; I. Okada; M. Matsumoto; M. Ishikawa; H. Matsumoto; Y. Toyama

In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone

M. Aizawa, M. Ito, K. Itatani, H. Suemasu, A. Nozue, I. Okada, M. Matsumoto, M. Ishikawa, H. Matsumoto, Y. Toyama

Research output: Contribution to journal › Conference article › peer-review

Abstract

We fabricated the Hydroxyapatite(HAp)-PMMA hybrid material having mechanical properties similar to those of the cortical bone, using porous HAp ceramics with well-controlled pore sizes and bulk polymerization of MMA monomer without solvents. The histological results showed that the present hybrid material bonded directly to bone without intervening fibrous tissue between hybrid material and newly formed bone, and that a large amount of new bone was formed around the hybrid material. In addition, the results of in vitro evaluation also showed that the hybrid material in the present investigation has good biocompatibility.

Original language	English
Pages (from-to)	465-468
Number of pages	4
Journal	Key Engineering Materials
Volume	218-220
Publication status	Published - 2002 Jan 1
Event	14th International Symposium on Ceramics in Medicine-Annual Meeting of the International Society for Ceramics in Medicine BIOCERAMICS'01 (ISCM) - Palm Springs, CA, United States Duration: 2001 Nov 14 → 2001 Nov 17

Keywords

Biocompatibility
Ceramics/Polymer Hybrid Material
Hydroxyapatite
Mechanical Property
Osteoblast
PMMA
Tissue Reaction

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone. / Aizawa, M.; Ito, M.; Itatani, K.; Suemasu, H.; Nozue, A.; Okada, I.; Matsumoto, M.; Ishikawa, M.; Matsumoto, H.; Toyama, Y.

In: Key Engineering Materials, Vol. 218-220, 01.01.2002, p. 465-468.

Research output: Contribution to journal › Conference article › peer-review

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title = "In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone",

abstract = "We fabricated the Hydroxyapatite(HAp)-PMMA hybrid material having mechanical properties similar to those of the cortical bone, using porous HAp ceramics with well-controlled pore sizes and bulk polymerization of MMA monomer without solvents. The histological results showed that the present hybrid material bonded directly to bone without intervening fibrous tissue between hybrid material and newly formed bone, and that a large amount of new bone was formed around the hybrid material. In addition, the results of in vitro evaluation also showed that the hybrid material in the present investigation has good biocompatibility.",

keywords = "Biocompatibility, Ceramics/Polymer Hybrid Material, Hydroxyapatite, Mechanical Property, Osteoblast, PMMA, Tissue Reaction",

author = "M. Aizawa and M. Ito and K. Itatani and H. Suemasu and A. Nozue and I. Okada and M. Matsumoto and M. Ishikawa and H. Matsumoto and Y. Toyama",

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T1 - In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone

AU - Aizawa, M.

AU - Ito, M.

AU - Itatani, K.

AU - Suemasu, H.

AU - Nozue, A.

AU - Okada, I.

AU - Matsumoto, M.

AU - Ishikawa, M.

AU - Matsumoto, H.

AU - Toyama, Y.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - We fabricated the Hydroxyapatite(HAp)-PMMA hybrid material having mechanical properties similar to those of the cortical bone, using porous HAp ceramics with well-controlled pore sizes and bulk polymerization of MMA monomer without solvents. The histological results showed that the present hybrid material bonded directly to bone without intervening fibrous tissue between hybrid material and newly formed bone, and that a large amount of new bone was formed around the hybrid material. In addition, the results of in vitro evaluation also showed that the hybrid material in the present investigation has good biocompatibility.

AB - We fabricated the Hydroxyapatite(HAp)-PMMA hybrid material having mechanical properties similar to those of the cortical bone, using porous HAp ceramics with well-controlled pore sizes and bulk polymerization of MMA monomer without solvents. The histological results showed that the present hybrid material bonded directly to bone without intervening fibrous tissue between hybrid material and newly formed bone, and that a large amount of new bone was formed around the hybrid material. In addition, the results of in vitro evaluation also showed that the hybrid material in the present investigation has good biocompatibility.

KW - Biocompatibility

KW - Ceramics/Polymer Hybrid Material

KW - Hydroxyapatite

KW - Mechanical Property

KW - Osteoblast

KW - PMMA

KW - Tissue Reaction

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M3 - Conference article

AN - SCOPUS:0036169858

VL - 218-220

SP - 465

EP - 468

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

T2 - 14th International Symposium on Ceramics in Medicine-Annual Meeting of the International Society for Ceramics in Medicine BIOCERAMICS'01 (ISCM)

Y2 - 14 November 2001 through 17 November 2001

ER -

In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone

Abstract

Keywords

ASJC Scopus subject areas

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