In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone

M. Aizawa, M. Ito, K. Itatani, H. Suemasu, A. Nozue, I. Okada, Morio Matsumoto, M. Ishikawa, Hideo Matsumoto, Y. Toyama

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We fabricated the Hydroxyapatite(HAp)-PMMA hybrid material having mechanical properties similar to those of the cortical bone, using porous HAp ceramics with well-controlled pore sizes and bulk polymerization of MMA monomer without solvents. The histological results showed that the present hybrid material bonded directly to bone without intervening fibrous tissue between hybrid material and newly formed bone, and that a large amount of new bone was formed around the hybrid material. In addition, the results of in vitro evaluation also showed that the hybrid material in the present investigation has good biocompatibility.

Original languageEnglish
Pages (from-to)465-468
Number of pages4
JournalKey Engineering Materials
Volume218-220
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Hybrid materials
Polymethyl Methacrylate
Durapatite
Biocompatibility
Hydroxyapatite
Bone
Mechanical properties
Pore size
Monomers
Polymerization
Tissue

Keywords

  • Biocompatibility
  • Ceramics/Polymer Hybrid Material
  • Hydroxyapatite
  • Mechanical Property
  • Osteoblast
  • PMMA
  • Tissue Reaction

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone. / Aizawa, M.; Ito, M.; Itatani, K.; Suemasu, H.; Nozue, A.; Okada, I.; Matsumoto, Morio; Ishikawa, M.; Matsumoto, Hideo; Toyama, Y.

In: Key Engineering Materials, Vol. 218-220, 2002, p. 465-468.

Research output: Contribution to journalArticle

Aizawa, M, Ito, M, Itatani, K, Suemasu, H, Nozue, A, Okada, I, Matsumoto, M, Ishikawa, M, Matsumoto, H & Toyama, Y 2002, 'In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone', Key Engineering Materials, vol. 218-220, pp. 465-468.
Aizawa, M. ; Ito, M. ; Itatani, K. ; Suemasu, H. ; Nozue, A. ; Okada, I. ; Matsumoto, Morio ; Ishikawa, M. ; Matsumoto, Hideo ; Toyama, Y. / In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone. In: Key Engineering Materials. 2002 ; Vol. 218-220. pp. 465-468.
@article{298c2e6c4c3545f18fe284eb8ab27126,
title = "In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone",
abstract = "We fabricated the Hydroxyapatite(HAp)-PMMA hybrid material having mechanical properties similar to those of the cortical bone, using porous HAp ceramics with well-controlled pore sizes and bulk polymerization of MMA monomer without solvents. The histological results showed that the present hybrid material bonded directly to bone without intervening fibrous tissue between hybrid material and newly formed bone, and that a large amount of new bone was formed around the hybrid material. In addition, the results of in vitro evaluation also showed that the hybrid material in the present investigation has good biocompatibility.",
keywords = "Biocompatibility, Ceramics/Polymer Hybrid Material, Hydroxyapatite, Mechanical Property, Osteoblast, PMMA, Tissue Reaction",
author = "M. Aizawa and M. Ito and K. Itatani and H. Suemasu and A. Nozue and I. Okada and Morio Matsumoto and M. Ishikawa and Hideo Matsumoto and Y. Toyama",
year = "2002",
language = "English",
volume = "218-220",
pages = "465--468",
journal = "Key Engineering Materials",
issn = "1013-9826",
publisher = "Trans Tech Publications",

}

TY - JOUR

T1 - In vivo and in vitro evaluation of the biocompatibility of the hydroxyapatite-PMMA hybrid materials having mechanical property similar to that of cortical bone

AU - Aizawa, M.

AU - Ito, M.

AU - Itatani, K.

AU - Suemasu, H.

AU - Nozue, A.

AU - Okada, I.

AU - Matsumoto, Morio

AU - Ishikawa, M.

AU - Matsumoto, Hideo

AU - Toyama, Y.

PY - 2002

Y1 - 2002

N2 - We fabricated the Hydroxyapatite(HAp)-PMMA hybrid material having mechanical properties similar to those of the cortical bone, using porous HAp ceramics with well-controlled pore sizes and bulk polymerization of MMA monomer without solvents. The histological results showed that the present hybrid material bonded directly to bone without intervening fibrous tissue between hybrid material and newly formed bone, and that a large amount of new bone was formed around the hybrid material. In addition, the results of in vitro evaluation also showed that the hybrid material in the present investigation has good biocompatibility.

AB - We fabricated the Hydroxyapatite(HAp)-PMMA hybrid material having mechanical properties similar to those of the cortical bone, using porous HAp ceramics with well-controlled pore sizes and bulk polymerization of MMA monomer without solvents. The histological results showed that the present hybrid material bonded directly to bone without intervening fibrous tissue between hybrid material and newly formed bone, and that a large amount of new bone was formed around the hybrid material. In addition, the results of in vitro evaluation also showed that the hybrid material in the present investigation has good biocompatibility.

KW - Biocompatibility

KW - Ceramics/Polymer Hybrid Material

KW - Hydroxyapatite

KW - Mechanical Property

KW - Osteoblast

KW - PMMA

KW - Tissue Reaction

UR - http://www.scopus.com/inward/record.url?scp=0036169858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036169858&partnerID=8YFLogxK

M3 - Article

VL - 218-220

SP - 465

EP - 468

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

ER -