In vivo antitumor activity of hexamethylmelamine against human breast, stomach and colon carcinoma xenografts

Hirokazu Tanino, Tetsuro Kubota, Yoshinori Yamada, Jun ichi Koh, Suguru Kase, Toshiharu Furukawa, Tsong Hong Kuo, Yoshiro Saikawa, Masaki Kitajima, Yasuaki Naito

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have evaluated the antitumor activity of Altretamine (hexamethylmelamine, HMM) on human carcinoma xenografts serially transplanted in nude mice. Five human breast carcinoma xenografts, MX-1, T-61, MCF-7, R-27 and Br-10, were inoculated subcutaneously into female nude mice. Two human stomach carcinoma xenografts, SC-1-NU and St-4, and three human colon carcinoma xenografts, Co-3, Co-4 and Co-6, were inoculated subcutaneously into male nude mice. One pellet of 17β-estradiol (0.1 mg/mouse) was inoculated subcutaneously in the mice transplanted with MCF-7 when the tumors were inoculated. HMM was administered per os daily for 4 weeks. MX-1 and T-61 tumors regressed completely after treatment with HMM at a dose of 75 mg/kg (the maximum tolerated dose: MTD) for MX-1 and 25 mg/kg for T-61. Br-10 was sensitive, whereas MCF-7 and R-27 were resistant to HMM at its MTD. HMM exerted the most potent antitumor effect against T-61. Against MX-1, it exerted an antitumor effect equivalent to that of cisplatin or cyclophosphamide. In addition, this agent was effective against all stomach and colon carcinoma xenografts, in particular St-4 ( T C% = 10.7: the mean tumor weight of treated group/the mean tumor weight of control group) and Co-3 ( T C%=31.5%) which are insensitive to presently available agents. HMM seems worthy of further clinical investigation as a candidate agent to treat breast, stomach, colon and other carcinomas.

Original languageEnglish
Pages (from-to)770-775
Number of pages6
JournalJapanese Journal of Cancer Research
Volume86
Issue number8
Publication statusPublished - 1995 Aug

Fingerprint

Altretamine
Heterografts
Stomach
Colon
Breast
Carcinoma
Nude Mice
Tumor Burden
Maximum Tolerated Dose
Cyclophosphamide
Cisplatin
Estradiol
Neoplasms
Breast Neoplasms
Control Groups
T 61

Keywords

  • Altretamine
  • Chemotherapy
  • Hexamethylmelamine
  • Nude mouse

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

In vivo antitumor activity of hexamethylmelamine against human breast, stomach and colon carcinoma xenografts. / Tanino, Hirokazu; Kubota, Tetsuro; Yamada, Yoshinori; Koh, Jun ichi; Kase, Suguru; Furukawa, Toshiharu; Kuo, Tsong Hong; Saikawa, Yoshiro; Kitajima, Masaki; Naito, Yasuaki.

In: Japanese Journal of Cancer Research, Vol. 86, No. 8, 08.1995, p. 770-775.

Research output: Contribution to journalArticle

Tanino, H, Kubota, T, Yamada, Y, Koh, JI, Kase, S, Furukawa, T, Kuo, TH, Saikawa, Y, Kitajima, M & Naito, Y 1995, 'In vivo antitumor activity of hexamethylmelamine against human breast, stomach and colon carcinoma xenografts', Japanese Journal of Cancer Research, vol. 86, no. 8, pp. 770-775.
Tanino, Hirokazu ; Kubota, Tetsuro ; Yamada, Yoshinori ; Koh, Jun ichi ; Kase, Suguru ; Furukawa, Toshiharu ; Kuo, Tsong Hong ; Saikawa, Yoshiro ; Kitajima, Masaki ; Naito, Yasuaki. / In vivo antitumor activity of hexamethylmelamine against human breast, stomach and colon carcinoma xenografts. In: Japanese Journal of Cancer Research. 1995 ; Vol. 86, No. 8. pp. 770-775.
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abstract = "We have evaluated the antitumor activity of Altretamine (hexamethylmelamine, HMM) on human carcinoma xenografts serially transplanted in nude mice. Five human breast carcinoma xenografts, MX-1, T-61, MCF-7, R-27 and Br-10, were inoculated subcutaneously into female nude mice. Two human stomach carcinoma xenografts, SC-1-NU and St-4, and three human colon carcinoma xenografts, Co-3, Co-4 and Co-6, were inoculated subcutaneously into male nude mice. One pellet of 17β-estradiol (0.1 mg/mouse) was inoculated subcutaneously in the mice transplanted with MCF-7 when the tumors were inoculated. HMM was administered per os daily for 4 weeks. MX-1 and T-61 tumors regressed completely after treatment with HMM at a dose of 75 mg/kg (the maximum tolerated dose: MTD) for MX-1 and 25 mg/kg for T-61. Br-10 was sensitive, whereas MCF-7 and R-27 were resistant to HMM at its MTD. HMM exerted the most potent antitumor effect against T-61. Against MX-1, it exerted an antitumor effect equivalent to that of cisplatin or cyclophosphamide. In addition, this agent was effective against all stomach and colon carcinoma xenografts, in particular St-4 ( T C{\%} = 10.7: the mean tumor weight of treated group/the mean tumor weight of control group) and Co-3 ( T C{\%}=31.5{\%}) which are insensitive to presently available agents. HMM seems worthy of further clinical investigation as a candidate agent to treat breast, stomach, colon and other carcinomas.",
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AU - Kase, Suguru

AU - Furukawa, Toshiharu

AU - Kuo, Tsong Hong

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AU - Kitajima, Masaki

AU - Naito, Yasuaki

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