In vivo bone marrow lipid characterization with line scan Carr-Purcell- Meiboom-Gill proton spectroscopic imaging

Robert V. Mulkern, Jiqun Meng, John L. Bowers, Koichi Oshio, Chun Zuo, Haicheng Li, Robert A. Kraft, Daniel S. Williamson, Diego Jaramillo

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Line scan Carr-Purcell-Meiboom-Gill spectroscopic imaging sequences have been used to extract lipid chemical composition indices in healthy adult bone marrow in the knee at 1.5 T. Since several spectroscopic echo readouts follow each excitation, the information acquired reflects a balance between spectral T2 decay processes and spectral resolution. To examine this balance in detail, data sets with two different echo spacings and spectral resolutions have been acquired to compare the information available from each in studies of bone marrow. Oils for which high field (7 T) proton spectra were recorded were used to evaluate the accuracy of lipid chemical composition indices extracted from the line scan Carr-Purcell-Meiboom-Gill spectroscopic imaging methods at 1.5 T. The extension of the method to fast spectroscopic imaging of bone marrow with multiple echoes is demonstrated.

Original languageEnglish
Pages (from-to)823-837
Number of pages15
JournalMagnetic Resonance Imaging
Volume15
Issue number7
DOIs
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

bone marrow
Lipids
lipids
Protons
echoes
Bone
Bone Marrow
Spectral resolution
Imaging techniques
spectral resolution
protons
chemical composition
Chemical analysis
readout
Knee
Oils
oils
spacing
decay
excitation

Keywords

  • Bone marrow
  • CPMG
  • Lipids
  • RARE
  • Spectroscopic imaging

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

In vivo bone marrow lipid characterization with line scan Carr-Purcell- Meiboom-Gill proton spectroscopic imaging. / Mulkern, Robert V.; Meng, Jiqun; Bowers, John L.; Oshio, Koichi; Zuo, Chun; Li, Haicheng; Kraft, Robert A.; Williamson, Daniel S.; Jaramillo, Diego.

In: Magnetic Resonance Imaging, Vol. 15, No. 7, 1997, p. 823-837.

Research output: Contribution to journalArticle

Mulkern, RV, Meng, J, Bowers, JL, Oshio, K, Zuo, C, Li, H, Kraft, RA, Williamson, DS & Jaramillo, D 1997, 'In vivo bone marrow lipid characterization with line scan Carr-Purcell- Meiboom-Gill proton spectroscopic imaging', Magnetic Resonance Imaging, vol. 15, no. 7, pp. 823-837. https://doi.org/10.1016/S0730-725X(97)00134-3
Mulkern, Robert V. ; Meng, Jiqun ; Bowers, John L. ; Oshio, Koichi ; Zuo, Chun ; Li, Haicheng ; Kraft, Robert A. ; Williamson, Daniel S. ; Jaramillo, Diego. / In vivo bone marrow lipid characterization with line scan Carr-Purcell- Meiboom-Gill proton spectroscopic imaging. In: Magnetic Resonance Imaging. 1997 ; Vol. 15, No. 7. pp. 823-837.
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