In Vivo Gold Complex Catalysis within Live Mice

Kazuki Tsubokura, Kenward K.H. Vong, Ambara R. Pradipta, Akihiro Ogura, Sayaka Urano, Tsuyoshi Tahara, Satoshi Nozaki, Hirotaka Onoe, Yoichi Nakao, Regina Sibgatullina, Almira Kurbangalieva, Yasuyoshi Watanabe, Katsunori Tanaka

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin–AuIII complex was designed and developed that enables organ-specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.

Original languageEnglish
Pages (from-to)3579-3584
Number of pages6
JournalAngewandte Chemie - International Edition
Volume56
Issue number13
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • amide bond formation
  • fluorescent labeling
  • glycoalbumin
  • gold catalysis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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  • Cite this

    Tsubokura, K., Vong, K. K. H., Pradipta, A. R., Ogura, A., Urano, S., Tahara, T., Nozaki, S., Onoe, H., Nakao, Y., Sibgatullina, R., Kurbangalieva, A., Watanabe, Y., & Tanaka, K. (2017). In Vivo Gold Complex Catalysis within Live Mice. Angewandte Chemie - International Edition, 56(13), 3579-3584. https://doi.org/10.1002/anie.201610273