In vivo kinetics and biodistribution analysis of neoglycoproteins: Effects of chemically introduced glycans on proteins

Akihiro Ogura; Almira Kurbangalieva; Katsunori Tanaka

doi:10.1007/s10719-014-9520-3

In vivo kinetics and biodistribution analysis of neoglycoproteins: Effects of chemically introduced glycans on proteins

Akihiro Ogura, Almira Kurbangalieva, Katsunori Tanaka

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Biodistribution and in vivo kinetics analysis of chemically prepared neoglycoproteins are reviewed. Various mono- and oligosaccharides were conjugated onto the protein surface by use of chemical methods. Their kinetic and organ-specific accumulation have extensively been studied after intravenous injection and analyzed by conventional dissection studies, as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies clearly show the glycan-structure dependency on protein kinetics, which will provide promising possibilities for pharmacological and diagnostic applications.

Original language	English
Pages (from-to)	273-279
Number of pages	7
Journal	Glycoconjugate Journal
Volume	31
Issue number	4
DOIs	https://doi.org/10.1007/s10719-014-9520-3
Publication status	Published - 2014 May
Externally published	Yes

Keywords

Albumin
Bioconjugation
Biodistribution
Chemical reaction
In vivo imaging
N-Glycans
Neoglycoprotein
Tumor targeting

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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AU - Ogura, Akihiro

AU - Kurbangalieva, Almira

AU - Tanaka, Katsunori

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AB - Biodistribution and in vivo kinetics analysis of chemically prepared neoglycoproteins are reviewed. Various mono- and oligosaccharides were conjugated onto the protein surface by use of chemical methods. Their kinetic and organ-specific accumulation have extensively been studied after intravenous injection and analyzed by conventional dissection studies, as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies clearly show the glycan-structure dependency on protein kinetics, which will provide promising possibilities for pharmacological and diagnostic applications.

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KW - Chemical reaction

KW - In vivo imaging

KW - N-Glycans

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KW - Tumor targeting

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