Abstract
Biodistribution and in vivo kinetics analysis of chemically prepared neoglycoproteins are reviewed. Various mono- and oligosaccharides were conjugated onto the protein surface by use of chemical methods. Their kinetic and organ-specific accumulation have extensively been studied after intravenous injection and analyzed by conventional dissection studies, as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies clearly show the glycan-structure dependency on protein kinetics, which will provide promising possibilities for pharmacological and diagnostic applications.
| Original language | English |
|---|---|
| Pages (from-to) | 273-279 |
| Number of pages | 7 |
| Journal | Glycoconjugate Journal |
| Volume | 31 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2014 |
| Externally published | Yes |
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Keywords
- Albumin
- Bioconjugation
- Biodistribution
- Chemical reaction
- In vivo imaging
- N-Glycans
- Neoglycoprotein
- Tumor targeting
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
In vivo kinetics and biodistribution analysis of neoglycoproteins : Effects of chemically introduced glycans on proteins. / Ogura, Akihiro; Kurbangalieva, Almira; Tanaka, Katsunori.
In: Glycoconjugate Journal, Vol. 31, No. 4, 2014, p. 273-279.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo kinetics and biodistribution analysis of neoglycoproteins
T2 - Effects of chemically introduced glycans on proteins
AU - Ogura, Akihiro
AU - Kurbangalieva, Almira
AU - Tanaka, Katsunori
PY - 2014
Y1 - 2014
N2 - Biodistribution and in vivo kinetics analysis of chemically prepared neoglycoproteins are reviewed. Various mono- and oligosaccharides were conjugated onto the protein surface by use of chemical methods. Their kinetic and organ-specific accumulation have extensively been studied after intravenous injection and analyzed by conventional dissection studies, as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies clearly show the glycan-structure dependency on protein kinetics, which will provide promising possibilities for pharmacological and diagnostic applications.
AB - Biodistribution and in vivo kinetics analysis of chemically prepared neoglycoproteins are reviewed. Various mono- and oligosaccharides were conjugated onto the protein surface by use of chemical methods. Their kinetic and organ-specific accumulation have extensively been studied after intravenous injection and analyzed by conventional dissection studies, as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies clearly show the glycan-structure dependency on protein kinetics, which will provide promising possibilities for pharmacological and diagnostic applications.
KW - Albumin
KW - Bioconjugation
KW - Biodistribution
KW - Chemical reaction
KW - In vivo imaging
KW - N-Glycans
KW - Neoglycoprotein
KW - Tumor targeting
UR - http://www.scopus.com/inward/record.url?scp=84901926759&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901926759&partnerID=8YFLogxK
U2 - 10.1007/s10719-014-9520-3
DO - 10.1007/s10719-014-9520-3
M3 - Article
VL - 31
SP - 273
EP - 279
JO - Glycoconjugate Journal
JF - Glycoconjugate Journal
SN - 0282-0080
IS - 4
ER -