In vivo kinetics and biodistribution analysis of neoglycoproteins: Effects of chemically introduced glycans on proteins

Akihiro Ogura, Almira Kurbangalieva, Katsunori Tanaka

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Biodistribution and in vivo kinetics analysis of chemically prepared neoglycoproteins are reviewed. Various mono- and oligosaccharides were conjugated onto the protein surface by use of chemical methods. Their kinetic and organ-specific accumulation have extensively been studied after intravenous injection and analyzed by conventional dissection studies, as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies clearly show the glycan-structure dependency on protein kinetics, which will provide promising possibilities for pharmacological and diagnostic applications.

Original languageEnglish
Pages (from-to)273-279
Number of pages7
JournalGlycoconjugate Journal
Volume31
Issue number4
DOIs
Publication statusPublished - 2014 May
Externally publishedYes

Keywords

  • Albumin
  • Bioconjugation
  • Biodistribution
  • Chemical reaction
  • In vivo imaging
  • N-Glycans
  • Neoglycoprotein
  • Tumor targeting

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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