In vivo kinetics and biodistribution analysis of neoglycoproteins: Effects of chemically introduced glycans on proteins

Akihiro Ogura; Almira Kurbangalieva; Katsunori Tanaka

doi:10.1007/s10719-014-9520-3

In vivo kinetics and biodistribution analysis of neoglycoproteins: Effects of chemically introduced glycans on proteins

Akihiro Ogura, Almira Kurbangalieva, Katsunori Tanaka

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Biodistribution and in vivo kinetics analysis of chemically prepared neoglycoproteins are reviewed. Various mono- and oligosaccharides were conjugated onto the protein surface by use of chemical methods. Their kinetic and organ-specific accumulation have extensively been studied after intravenous injection and analyzed by conventional dissection studies, as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies clearly show the glycan-structure dependency on protein kinetics, which will provide promising possibilities for pharmacological and diagnostic applications.

Original language	English
Pages (from-to)	273-279
Number of pages	7
Journal	Glycoconjugate Journal
Volume	31
Issue number	4
DOIs	https://doi.org/10.1007/s10719-014-9520-3
Publication status	Published - 2014 May
Externally published	Yes

Keywords

Albumin
Bioconjugation
Biodistribution
Chemical reaction
In vivo imaging
N-Glycans
Neoglycoprotein
Tumor targeting

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "In vivo kinetics and biodistribution analysis of neoglycoproteins: Effects of chemically introduced glycans on proteins",

abstract = "Biodistribution and in vivo kinetics analysis of chemically prepared neoglycoproteins are reviewed. Various mono- and oligosaccharides were conjugated onto the protein surface by use of chemical methods. Their kinetic and organ-specific accumulation have extensively been studied after intravenous injection and analyzed by conventional dissection studies, as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies clearly show the glycan-structure dependency on protein kinetics, which will provide promising possibilities for pharmacological and diagnostic applications.",

keywords = "Albumin, Bioconjugation, Biodistribution, Chemical reaction, In vivo imaging, N-Glycans, Neoglycoprotein, Tumor targeting",

author = "Akihiro Ogura and Almira Kurbangalieva and Katsunori Tanaka",

note = "Funding Information: Acknowledgments The authors are supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, 22651081, 23681047, and 25560410, by a Research Grant from the Mizutani Foundation for Glycoscience, by a MEXT Grant-in-Aid for Scientific Research on Innovative Areas “Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity”, by an AstraZeneca R&D Grant, and by a subsidy of the Russian Government “Program of Competitive Growth of Kazan Federal University among World's Leading Academic Centers”.",

year = "2014",

month = may,

doi = "10.1007/s10719-014-9520-3",

language = "English",

volume = "31",

pages = "273--279",

journal = "Glycoconjugate Journal",

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number = "4",

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T2 - Effects of chemically introduced glycans on proteins

AU - Ogura, Akihiro

AU - Kurbangalieva, Almira

AU - Tanaka, Katsunori

N1 - Funding Information: Acknowledgments The authors are supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, 22651081, 23681047, and 25560410, by a Research Grant from the Mizutani Foundation for Glycoscience, by a MEXT Grant-in-Aid for Scientific Research on Innovative Areas “Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity”, by an AstraZeneca R&D Grant, and by a subsidy of the Russian Government “Program of Competitive Growth of Kazan Federal University among World's Leading Academic Centers”.

PY - 2014/5

Y1 - 2014/5

N2 - Biodistribution and in vivo kinetics analysis of chemically prepared neoglycoproteins are reviewed. Various mono- and oligosaccharides were conjugated onto the protein surface by use of chemical methods. Their kinetic and organ-specific accumulation have extensively been studied after intravenous injection and analyzed by conventional dissection studies, as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies clearly show the glycan-structure dependency on protein kinetics, which will provide promising possibilities for pharmacological and diagnostic applications.

AB - Biodistribution and in vivo kinetics analysis of chemically prepared neoglycoproteins are reviewed. Various mono- and oligosaccharides were conjugated onto the protein surface by use of chemical methods. Their kinetic and organ-specific accumulation have extensively been studied after intravenous injection and analyzed by conventional dissection studies, as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies clearly show the glycan-structure dependency on protein kinetics, which will provide promising possibilities for pharmacological and diagnostic applications.

KW - Albumin

KW - Bioconjugation

KW - Biodistribution

KW - Chemical reaction

KW - In vivo imaging

KW - N-Glycans

KW - Neoglycoprotein

KW - Tumor targeting

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JO - Glycoconjugate Journal

JF - Glycoconjugate Journal

SN - 0282-0080

IS - 4

ER -

In vivo kinetics and biodistribution analysis of neoglycoproteins: Effects of chemically introduced glycans on proteins

Abstract

Keywords

ASJC Scopus subject areas

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