In vivo kinetics and biodistribution analysis of neoglycoproteins

Effects of chemically introduced glycans on proteins

Akihiro Ogura, Almira Kurbangalieva, Katsunori Tanaka

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Biodistribution and in vivo kinetics analysis of chemically prepared neoglycoproteins are reviewed. Various mono- and oligosaccharides were conjugated onto the protein surface by use of chemical methods. Their kinetic and organ-specific accumulation have extensively been studied after intravenous injection and analyzed by conventional dissection studies, as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies clearly show the glycan-structure dependency on protein kinetics, which will provide promising possibilities for pharmacological and diagnostic applications.

Original languageEnglish
Pages (from-to)273-279
Number of pages7
JournalGlycoconjugate Journal
Volume31
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Polysaccharides
Glycoproteins
Kinetics
Dissection
Proteins
Monosaccharides
Optical Imaging
Single-Photon Emission-Computed Tomography
Oligosaccharides
Intravenous Injections
Membrane Proteins
Fluorescence
Pharmacology
Imaging techniques

Keywords

  • Albumin
  • Bioconjugation
  • Biodistribution
  • Chemical reaction
  • In vivo imaging
  • N-Glycans
  • Neoglycoprotein
  • Tumor targeting

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

In vivo kinetics and biodistribution analysis of neoglycoproteins : Effects of chemically introduced glycans on proteins. / Ogura, Akihiro; Kurbangalieva, Almira; Tanaka, Katsunori.

In: Glycoconjugate Journal, Vol. 31, No. 4, 2014, p. 273-279.

Research output: Contribution to journalArticle

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