In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse

Misa Suzuki-Anekoji, Atsushi Suzuki, Sz Wei Wu, Kiyohiko Angata, Keith K. Murai, Kazuhiro Sugihara, Tomoya O. Akama, Kay Hooi Khoo, Jun Nakayama, Michiko N. Fukuda, Minoru Fukuda

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Chst10 transfers sulfate to glucuronic acid to form the HNK-1 antigen carried by glycoproteins and glycolipids in neurons and NK cells. Results: Chst10 transfers sulfate to glucuronidated steroid hormones, and Chst10-deficient mice exhibited subfertility. Conclusion: Subfertility in Chst10 null females is caused by a loss of steroid hormone dysregulation. Significance: This study identified a new regulatory mechanism mediated by sulfation of glucuronidated steroid.

Original languageEnglish
Pages (from-to)5007-5016
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number7
DOIs
Publication statusPublished - 2013 Feb 15

Fingerprint

Steroid hormones
Sulfotransferases
Sulfates
CD57 Antigens
Steroids
Hormones
Glucuronic Acid
Infertility
Glycolipids
Neurons
Glycoproteins
Natural Killer Cells

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Suzuki-Anekoji, M., Suzuki, A., Wu, S. W., Angata, K., Murai, K. K., Sugihara, K., ... Fukuda, M. (2013). In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse. Journal of Biological Chemistry, 288(7), 5007-5016. https://doi.org/10.1074/jbc.M112.433474

In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse. / Suzuki-Anekoji, Misa; Suzuki, Atsushi; Wu, Sz Wei; Angata, Kiyohiko; Murai, Keith K.; Sugihara, Kazuhiro; Akama, Tomoya O.; Khoo, Kay Hooi; Nakayama, Jun; Fukuda, Michiko N.; Fukuda, Minoru.

In: Journal of Biological Chemistry, Vol. 288, No. 7, 15.02.2013, p. 5007-5016.

Research output: Contribution to journalArticle

Suzuki-Anekoji, M, Suzuki, A, Wu, SW, Angata, K, Murai, KK, Sugihara, K, Akama, TO, Khoo, KH, Nakayama, J, Fukuda, MN & Fukuda, M 2013, 'In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse', Journal of Biological Chemistry, vol. 288, no. 7, pp. 5007-5016. https://doi.org/10.1074/jbc.M112.433474
Suzuki-Anekoji M, Suzuki A, Wu SW, Angata K, Murai KK, Sugihara K et al. In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse. Journal of Biological Chemistry. 2013 Feb 15;288(7):5007-5016. https://doi.org/10.1074/jbc.M112.433474
Suzuki-Anekoji, Misa ; Suzuki, Atsushi ; Wu, Sz Wei ; Angata, Kiyohiko ; Murai, Keith K. ; Sugihara, Kazuhiro ; Akama, Tomoya O. ; Khoo, Kay Hooi ; Nakayama, Jun ; Fukuda, Michiko N. ; Fukuda, Minoru. / In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 7. pp. 5007-5016.
@article{c6b1ddc2d30a4c0abae1513794ea02f8,
title = "In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse",
abstract = "Background: Chst10 transfers sulfate to glucuronic acid to form the HNK-1 antigen carried by glycoproteins and glycolipids in neurons and NK cells. Results: Chst10 transfers sulfate to glucuronidated steroid hormones, and Chst10-deficient mice exhibited subfertility. Conclusion: Subfertility in Chst10 null females is caused by a loss of steroid hormone dysregulation. Significance: This study identified a new regulatory mechanism mediated by sulfation of glucuronidated steroid.",
author = "Misa Suzuki-Anekoji and Atsushi Suzuki and Wu, {Sz Wei} and Kiyohiko Angata and Murai, {Keith K.} and Kazuhiro Sugihara and Akama, {Tomoya O.} and Khoo, {Kay Hooi} and Jun Nakayama and Fukuda, {Michiko N.} and Minoru Fukuda",
year = "2013",
month = "2",
day = "15",
doi = "10.1074/jbc.M112.433474",
language = "English",
volume = "288",
pages = "5007--5016",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "7",

}

TY - JOUR

T1 - In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse

AU - Suzuki-Anekoji, Misa

AU - Suzuki, Atsushi

AU - Wu, Sz Wei

AU - Angata, Kiyohiko

AU - Murai, Keith K.

AU - Sugihara, Kazuhiro

AU - Akama, Tomoya O.

AU - Khoo, Kay Hooi

AU - Nakayama, Jun

AU - Fukuda, Michiko N.

AU - Fukuda, Minoru

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Background: Chst10 transfers sulfate to glucuronic acid to form the HNK-1 antigen carried by glycoproteins and glycolipids in neurons and NK cells. Results: Chst10 transfers sulfate to glucuronidated steroid hormones, and Chst10-deficient mice exhibited subfertility. Conclusion: Subfertility in Chst10 null females is caused by a loss of steroid hormone dysregulation. Significance: This study identified a new regulatory mechanism mediated by sulfation of glucuronidated steroid.

AB - Background: Chst10 transfers sulfate to glucuronic acid to form the HNK-1 antigen carried by glycoproteins and glycolipids in neurons and NK cells. Results: Chst10 transfers sulfate to glucuronidated steroid hormones, and Chst10-deficient mice exhibited subfertility. Conclusion: Subfertility in Chst10 null females is caused by a loss of steroid hormone dysregulation. Significance: This study identified a new regulatory mechanism mediated by sulfation of glucuronidated steroid.

UR - http://www.scopus.com/inward/record.url?scp=84874051251&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874051251&partnerID=8YFLogxK

U2 - 10.1074/jbc.M112.433474

DO - 10.1074/jbc.M112.433474

M3 - Article

VL - 288

SP - 5007

EP - 5016

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 7

ER -