In vivo role of IFN-γ produced by antigen-presenting cells in early host defense against intracellular pathogens

Kazutomo Suzue, Takashi Asai, Tsutomu Takeuchi, Shigeo Koyasu

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Antigen-presenting cells (APC), including dendritic cells and macrophages, produce a large amount of interferon (IFN)-γ, a crucial cytokine for the control of infectious diseases. To elucidate the role of IFN-γ from APC in vivo, we employed cytokine receptor common γ subunit (γc) and recombination-activating gene (Rag -2 double-knockout (γc-/-(y)-Rag-2-/-) mice, which are severely impaired in IFN-γ production and are extremely susceptible to infection of intracellular pathogens including Listeria monocytogenes and Toxoplasma gondii. Adoptive transfer of IFN-γ-producing APC increased levels of serum IFN-γ and the resistance to Listeria. Although depletion of NK cells from Rag-2-/- mice slightly increased the susceptibility to bacterial infection, they are substantially more resistant than γc-/-(y)-Rag-2-/- mice, which are also devoid of all lymphoid cells. These results demonstrate that the APC-derived IFN-γ contributes to the control of infectious agents in vivo.

Original languageEnglish
Pages (from-to)2666-2675
Number of pages10
JournalEuropean Journal of Immunology
Volume33
Issue number10
DOIs
Publication statusPublished - 2003 Oct 1

Keywords

  • Dendritic cells
  • Listeria monocytogenes
  • Macrophage
  • NK cells
  • X-linked SCID

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'In vivo role of IFN-γ produced by antigen-presenting cells in early host defense against intracellular pathogens'. Together they form a unique fingerprint.

  • Cite this