In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice

Amy H. Yang, Isao Ishii, Jerold Chun

Research output: Contribution to journalReview article

75 Citations (Scopus)

Abstract

Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are extracellular ligands for a family of G protein-coupled receptors (GPCRs), LPA1/2/3 and S1P1/2/3/4/5. Through coupling to multiple classes of G proteins and activating multiple signaling pathways, LPA/S1P receptors have been shown to be integral players for many essential cellular and physiological processes. Generation and analysis of mice deficient in each of LPA1, LPA2, S1P1, S1P2, and S1P3 have provided valuable information on the in vivo roles of these receptors. This review is focussed on expression patterns of each receptor gene in wild-type mice, targeted deletion approaches for generating mutant animals, main phenotypes of receptor-null mice, and alterations in signaling characteristics in receptor-deficient primary cells. Altogether, these data give insights to the importance of LPA/S1P receptors at the cellular and organismal level.

Original languageEnglish
Pages (from-to)197-203
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1582
Issue number1-3
DOIs
Publication statusPublished - 2002 May 23

Keywords

  • LPA receptor
  • Lysophosphatidic acid
  • Lysophospholipid
  • S1P receptor
  • Signal transduction
  • Sphingosine 1-phosphate

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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